Protein interactions for MYC - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MYC
Gene descriptionⁱ Full gene name according to HGNC.	MYC proto-oncogene, bHLH transcription factor
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Cancer-related genes Disease related genes Human disease related genes Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane, Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	13

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Skin - Cornification (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Tissue enhanced (adipose tissue, skin)
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.37
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Nucleoplasm
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Skin - Cornification

Field

Cluster

Pathway

Number of interactions:

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
MAX	Direct interaction	High	0.98	22
TRRAP	Physical association	High	0.85	5
FBXW7	Physical association	High	0.83	7
KPNA4	Direct interaction	High	0.78	21
ZBTB17	Direct interaction	High	0.78	5
EP400	Physical association	High	0.76	5
GTF3C3	Physical association	High	0.75	41
CCAR2	Physical association	High	0.75	6
MCM7	Physical association	High	0.73	25
PIN1	Direct interaction	High	0.71	112
UBC	Physical association	High	0.69	56
EFTUD2	Physical association	High	0.68	10
LRPPRC	Physical association	High	0.67	6
PRPF6	Physical association	High	0.67	16
SMC4	Physical association	High	0.67	4
ATXN10	Physical association	High	0.67	35
KDM1A	Physical association	High	0.67	86
TRIP12	Direct interaction	High	0.63	2
SNIP1	Physical association	High	0.63	21
AXIN1	Direct interaction	High	0.62	40
SIN3B	Physical association	High	0.61	1
SIRT1	Direct interaction	High	0.6	44
CDK4	Direct interaction	Medium	0.59	24
FBXW8	Physical association	Medium	0.57	2
ACACA	Physical association	Medium	0.56	5
ARHGEF2	Physical association	Medium	0.56	7
ATP2A2	Physical association	Medium	0.56	4
COPG1	Physical association	Medium	0.56	4
CTPS1	Physical association	Medium	0.56	2
DDX20	Physical association	Medium	0.56	9
DDX24	Physical association	Medium	0.56	3
HDAC2	Physical association	Medium	0.56	16
HELLS	Physical association	Medium	0.56	2
HNRNPC	Physical association	Medium	0.56	25
IPO4	Physical association	Medium	0.56	6
IPO9	Physical association	Medium	0.56	3
IQGAP2	Physical association	Medium	0.56	3
MAP7D1	Physical association	Medium	0.56	1
MARS1	Physical association	Medium	0.56	1
MMS19	Physical association	Medium	0.56	8
MSH6	Physical association	Medium	0.56	3
MYBBP1A	Physical association	Medium	0.56	1
NOP56	Physical association	Medium	0.56	2
NUP133	Physical association	Medium	0.56	6
NUP93	Physical association	Medium	0.56	6
OPA1	Physical association	Medium	0.56	5
PDS5B	Physical association	Medium	0.56	9
POLE	Physical association	Medium	0.56	3
POLR2B	Physical association	Medium	0.56	3
RFC4	Physical association	Medium	0.56	6
SMARCC1	Physical association	Medium	0.56	31
SMC2	Physical association	Medium	0.56	5
SNRNP200	Physical association	Medium	0.56	12
TOP1	Physical association	Medium	0.56	5
TRIM28	Physical association	Medium	0.56	13
UBTF	Physical association	Medium	0.56	3
XPO5	Physical association	Medium	0.56	3
CASP6	Physical association	Medium	0.56	122
CBX5	Physical association	Medium	0.56	59
CCK	Physical association	Medium	0.56	32
DR1	Physical association	Medium	0.56	46
FGFR3	Physical association	Medium	0.56	192
GSN	Physical association	Medium	0.56	126
GTF2B	Physical association	Medium	0.56	34
SH3GLB1	Physical association	Medium	0.56	116
STIP1	Physical association	Medium	0.56	19
TARDBP	Physical association	Medium	0.56	141
TGFBR2	Physical association	Medium	0.56	54
UBQLN1	Physical association	Medium	0.56	213
GCN1	Physical association	Medium	0.55	1
KPNA2	Physical association	Medium	0.55	32
PSMC3	Physical association	Medium	0.55	20
SKP1	Physical association	Medium	0.55	51
CIP2A	Direct interaction	Medium	0.54	3
TP53BP1	Physical association	Medium	0.54	71
WDR5	Physical association	Medium	0.54	48
BRD3	Physical association	Medium	0.52	1
CEP57	Physical association	Medium	0.52	12
FOXO3	Physical association	Medium	0.52	17
SIRT6	Physical association	Medium	0.52	4
MIF4GD	Physical association	Medium	0.51	9
CHD4	Physical association	Medium	0.5	3
MBD3	Physical association	Medium	0.5	14
PIAS2	Physical association	Medium	0.5	16
SP1	Physical association	Medium	0.5	24
ZNF121	Physical association	Medium	0.48	7
CHUK	Physical association	Medium	0.46	17
IKBKG	Physical association	Medium	0.46	57
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
MYC is not a metabolic protein