Protein interactions for RNF11 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RNF11
Gene descriptionⁱ Full gene name according to HGNC.	Ring finger protein 11
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Basic cellular processes (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.20
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Not available
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Non-specific - Basic cellular processes

Field

Cluster

Pathway

Number of interactions:

153

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
UBE2D4	Physical association	High	0.88	39
UBE2D2	Direct interaction	High	0.84	40
QARS1	Physical association	High	0.83	53
GGA1	Direct interaction	High	0.8	15
UBE2D1	Direct interaction	High	0.79	39
NEDD4	Direct interaction	High	0.79	18
SMURF2	Direct interaction	High	0.74	10
UBE2N	Direct interaction	High	0.73	26
STAMBP	Physical association	High	0.7	21
UBE2V1	Direct interaction	High	0.68	23
RNF168	Physical association	High	0.67	5
RPS27A	Physical association	High	0.67	15
STAM2	Physical association	High	0.67	31
UBA52	Physical association	High	0.67	14
UBE2E3	Physical association	High	0.67	24
UBQLN2	Physical association	High	0.67	212
WWP2	Physical association	High	0.67	51
UBB	Direct interaction	High	0.65	31
UBE2D3	Direct interaction	High	0.65	25
TAX1BP1	Physical association	Medium	0.57	58
TNFAIP3	Physical association	Medium	0.57	14
ANXA8	Physical association	Medium	0.56	14
APP	Physical association	Medium	0.56	312
AQP8	Physical association	Medium	0.56	11
ARFGAP3	Physical association	Medium	0.56	29
ASB13	Physical association	Medium	0.56	10
ASCL4	Physical association	Medium	0.56	34
ATG10	Physical association	Medium	0.56	10
ATP6V1B1	Physical association	Medium	0.56	8
ATP6V1B2	Physical association	Medium	0.56	7
BAK1	Physical association	Medium	0.56	18
BECN1	Physical association	Medium	0.56	48
BRK1	Physical association	Medium	0.56	46
BSND	Physical association	Medium	0.56	25
C17orf49	Physical association	Medium	0.56	6
C7orf31	Physical association	Medium	0.56	15
C8orf48	Physical association	Medium	0.56	17
CLIP3	Physical association	Medium	0.56	5
CNPY3	Physical association	Medium	0.56	9
COPS3	Physical association	Medium	0.56	42
CSTA	Physical association	Medium	0.56	5
CXorf38	Physical association	Medium	0.56	10
CYB5A	Physical association	Medium	0.56	3
DMRTA1	Physical association	Medium	0.56	2
DPYSL5	Physical association	Medium	0.56	16
ESM1	Physical association	Medium	0.56	7
ESRP1	Physical association	Medium	0.56	28
EYA3	Physical association	Medium	0.56	8
FABP7	Physical association	Medium	0.56	5
FAM117B	Physical association	Medium	0.56	21
FAM163A	Physical association	Medium	0.56	17
FAM98C	Physical association	Medium	0.56	9
FANCL	Physical association	Medium	0.56	36
FOSL1	Physical association	Medium	0.56	17
G6PC1	Physical association	Medium	0.56	2
GFOD1	Physical association	Medium	0.56	17
GNB2	Physical association	Medium	0.56	26
GPANK1	Physical association	Medium	0.56	65
GPR141	Physical association	Medium	0.56	8
GPSM3	Physical association	Medium	0.56	38
H3-5	Physical association	Medium	0.56	17
H3C1	Physical association	Medium	0.56	52
H3C10	Physical association	Medium	0.56	52
H3C11	Physical association	Medium	0.56	52
H3C12	Physical association	Medium	0.56	52
H3C2	Physical association	Medium	0.56	52
H3C3	Physical association	Medium	0.56	52
H3C4	Physical association	Medium	0.56	52
H3C6	Physical association	Medium	0.56	52
H3C7	Physical association	Medium	0.56	52
H3C8	Physical association	Medium	0.56	52
HK3	Physical association	Medium	0.56	6
HOXC4	Physical association	Medium	0.56	22
ING4	Physical association	Medium	0.56	11
IQCF2	Physical association	Medium	0.56	5
IQUB	Physical association	Medium	0.56	56
KCTD13	Physical association	Medium	0.56	22
KLF15	Physical association	Medium	0.56	30
KLHL20	Physical association	Medium	0.56	31
KRT33B	Physical association	Medium	0.56	65
KRTAP19-7	Physical association	Medium	0.56	71
KRTAP8-1	Physical association	Medium	0.56	76
LCE1B	Physical association	Medium	0.56	69
LHX6	Physical association	Medium	0.56	18
LHX8	Physical association	Medium	0.56	28
LNX1	Physical association	Medium	0.56	333
LOXL4	Physical association	Medium	0.56	15
LPIN1	Physical association	Medium	0.56	18
METTL27	Physical association	Medium	0.56	41
MLC1	Physical association	Medium	0.56	13
MNAT1	Physical association	Medium	0.56	5
MPND	Physical association	Medium	0.56	15
NGEF	Physical association	Medium	0.56	8
NR1D2	Physical association	Medium	0.56	10
OTUB1	Physical association	Medium	0.56	43
PCMTD2	Physical association	Medium	0.56	8
PLEKHG7	Physical association	Medium	0.56	18
PRKAA2	Physical association	Medium	0.56	78
PRKAB2	Physical association	Medium	0.56	126
PRPS2	Physical association	Medium	0.56	10
PSMB10	Physical association	Medium	0.56	7
PSMB4	Physical association	Medium	0.56	31
RAI2	Physical association	Medium	0.56	13
RBM14	Physical association	Medium	0.56	11
RNF10	Physical association	Medium	0.56	13
RNF112	Physical association	Medium	0.56	18
RNF138	Physical association	Medium	0.56	18
RNF14	Physical association	Medium	0.56	6
RNF183	Physical association	Medium	0.56	30
RNF208	Physical association	Medium	0.56	20
RPS15A	Physical association	Medium	0.56	8
RYBP	Physical association	Medium	0.56	44
SAMD7	Physical association	Medium	0.56	5
SDC2	Physical association	Medium	0.56	7
SDCBP	Physical association	Medium	0.56	240
SH3KBP1	Physical association	Medium	0.56	33
SKIC8	Physical association	Medium	0.56	30
SNAPC3	Physical association	Medium	0.56	10
SNW1	Physical association	Medium	0.56	89
SPRED2	Physical association	Medium	0.56	38
SPRY4	Physical association	Medium	0.56	30
SPSB1	Physical association	Medium	0.56	19
SPSB2	Physical association	Medium	0.56	8
SYT3	Physical association	Medium	0.56	7
TASOR2	Physical association	Medium	0.56	34
TBPL1	Physical association	Medium	0.56	7
TCEAL8	Physical association	Medium	0.56	8
TDG	Physical association	Medium	0.56	13
TENT5B	Physical association	Medium	0.56	57
TEX19	Physical association	Medium	0.56	6
TIMM17B	Physical association	Medium	0.56	18
TLE1	Physical association	Medium	0.56	13
TMEM61	Physical association	Medium	0.56	11
TOLLIP	Physical association	Medium	0.56	41
TRIM21	Physical association	Medium	0.56	24
TSC22D4	Physical association	Medium	0.56	30
UBAC1	Physical association	Medium	0.56	24
VDAC2	Physical association	Medium	0.56	19
VPS37A	Physical association	Medium	0.56	18
VSX2	Physical association	Medium	0.56	20
WDR77	Physical association	Medium	0.56	6
WDR83	Physical association	Medium	0.56	30
XRCC6	Physical association	Medium	0.56	21
ZKSCAN8	Physical association	Medium	0.56	14
ZNF296	Physical association	Medium	0.56	9
ZNF366	Physical association	Medium	0.56	22
ZNF497	Physical association	Medium	0.56	41
ZNF524	Physical association	Medium	0.56	22
ZNF57	Physical association	Medium	0.56	14
ZNF670	Physical association	Medium	0.56	19
ZXDC	Physical association	Medium	0.56	19
ITCH	Direct interaction	Medium	0.54	17
UBE2E1	Direct interaction	Medium	0.53	8
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
RNF11 is not a metabolic protein