Protein interactions for ATXN1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ATXN1
Gene descriptionⁱ Full gene name according to HGNC.	Ataxin 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Unknown function (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.30
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Nucleoplasm In addition localized to the Nucleoli, Cytosol
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

Highlight:

Off

Subcell location

Predicted location

Tissue specificity

Protein class

Filter menu »

e.g. Brain enriched, Localized to mitochondria, Non-specific - Unknown function

Field

Cluster

Pathway

Number of interactions:

271

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
C1orf94	Physical association	High	0.86	69
TRAF2	Physical association	High	0.86	237
YWHAE	Direct interaction	High	0.85	42
YWHAZ	Direct interaction	High	0.84	128
TENT5B	Physical association	High	0.83	57
ESRP1	Physical association	High	0.81	28
RBFOX2	Physical association	High	0.79	18
ZNF488	Physical association	High	0.78	10
CRK	Physical association	High	0.77	54
ZC3H10	Physical association	High	0.76	28
CIC	Physical association	High	0.76	4
YWHAH	Physical association	High	0.74	31
ARID5A	Physical association	High	0.74	94
TCAP	Physical association	High	0.74	34
TENT5A	Physical association	High	0.74	3
CAMK1	Physical association	High	0.72	3
METTL27	Physical association	High	0.72	41
KAT5	Physical association	High	0.71	180
CFL1	Physical association	High	0.7	12
ELP5	Physical association	High	0.7	2
KLHL12	Physical association	High	0.7	40
NUDT21	Physical association	High	0.7	20
RBPMS	Physical association	High	0.7	105
TRIM32	Physical association	High	0.7	30
TRIM38	Physical association	High	0.7	17
ZHX1	Physical association	High	0.7	4
SKP1	Physical association	High	0.7	51
TBL1XR1	Physical association	High	0.7	5
EFEMP2	Physical association	High	0.7	83
U2AF2	Physical association	High	0.67	18
BAG2	Physical association	High	0.67	12
BUB3	Physical association	High	0.67	6
ELAVL1	Physical association	High	0.67	3
HSPA8	Physical association	High	0.67	35
PRDX4	Physical association	High	0.67	5
PSMA4	Physical association	High	0.67	13
SPCS3	Physical association	High	0.67	4
SQSTM1	Physical association	High	0.67	36
TPM3	Physical association	High	0.67	25
U2AF1	Physical association	High	0.67	26
YWHAB	Physical association	High	0.67	78
YWHAQ	Physical association	High	0.67	54
AHDC1	Physical association	High	0.67	2
ATP6V0D1	Physical association	High	0.67	6
CIRBP	Physical association	High	0.67	11
COIL	Physical association	High	0.67	35
DMPK	Physical association	High	0.67	3
DNAJA3	Physical association	High	0.67	9
DZIP3	Physical association	High	0.67	24
EIF1AY	Physical association	High	0.67	2
EIF3F	Physical association	High	0.67	42
EIF4ENIF1	Physical association	High	0.67	20
FDPS	Physical association	High	0.67	6
FYN	Physical association	High	0.67	46
GCA	Physical association	High	0.67	9
GMEB2	Physical association	High	0.67	12
HPCAL1	Physical association	High	0.67	31
HSFX1	Physical association	High	0.67	8
HSFX2	Physical association	High	0.67	8
LRSAM1	Physical association	High	0.67	7
NARS1	Physical association	High	0.67	1
NLK	Physical association	High	0.67	11
PEPD	Physical association	High	0.67	2
PHPT1	Physical association	High	0.67	1
PIAS1	Physical association	High	0.67	38
PIM2	Physical association	High	0.67	2
PRRC2B	Physical association	High	0.67	2
PSMC3	Physical association	High	0.67	20
PTGDS	Physical association	High	0.67	10
RCN1	Physical association	High	0.67	19
RNF31	Physical association	High	0.67	11
SLC51A	Physical association	High	0.67	2
SREBF1	Physical association	High	0.67	2
ST6GALNAC6	Physical association	High	0.67	2
STAC2	Physical association	High	0.67	3
STAM2	Physical association	High	0.67	31
SUPT20H	Physical association	High	0.67	2
TOLLIP	Physical association	High	0.67	41
TOX4	Physical association	High	0.67	7
TRIP6	Physical association	High	0.67	90
TTC19	Physical association	High	0.67	33
UBE2E3	Physical association	High	0.67	24
UBE2I	Physical association	High	0.67	40
VSNL1	Physical association	High	0.67	12
VSTM2L	Physical association	High	0.67	2
ZNF276	Physical association	High	0.67	9
ZXDC	Physical association	High	0.67	19
KLF3	Physical association	High	0.66	28
KLF5	Physical association	High	0.66	6
TBR1	Physical association	High	0.66	7
RBPJ	Physical association	High	0.64	12
HIVEP1	Physical association	High	0.63	5
CRYBA2	Physical association	High	0.61	21
RHOXF2	Physical association	High	0.61	52
ZBTB43	Physical association	High	0.61	21
UBQLN4	Physical association	Medium	0.59	20
RBM17	Physical association	Medium	0.58	21
ABTB1	Physical association	Medium	0.56	4
AK2	Physical association	Medium	0.56	7
AKT1	Physical association	Medium	0.56	58
ALG2	Physical association	Medium	0.56	2
ANP32A	Physical association	Medium	0.56	3
ANXA8	Physical association	Medium	0.56	14
APP	Physical association	Medium	0.56	312
ASB13	Physical association	Medium	0.56	10
ATF3	Physical association	Medium	0.56	17
ATG10	Physical association	Medium	0.56	10
ATP5F1B	Physical association	Medium	0.56	9
ATP5F1D	Physical association	Medium	0.56	7
ATP5PB	Physical association	Medium	0.56	12
ATP6V1B1	Physical association	Medium	0.56	8
BECN1	Physical association	Medium	0.56	48
BHLHE40	Physical association	Medium	0.56	52
BICRAL	Physical association	Medium	0.56	13
C20orf141	Physical association	Medium	0.56	4
C2orf49	Physical association	Medium	0.56	2
C6orf141	Physical association	Medium	0.56	8
CBL	Physical association	Medium	0.56	34
CBLC	Physical association	Medium	0.56	6
CCNB1IP1	Physical association	Medium	0.56	11
CCT5	Physical association	Medium	0.56	28
CCT6A	Physical association	Medium	0.56	9
CDC23	Physical association	Medium	0.56	69
CDC26	Physical association	Medium	0.56	4
CENPV	Physical association	Medium	0.56	14
CISH	Physical association	Medium	0.56	4
CRLF3	Physical association	Medium	0.56	24
CRX	Physical association	Medium	0.56	74
CUL4A	Physical association	Medium	0.56	12
CUTC	Physical association	Medium	0.56	12
DLX3	Physical association	Medium	0.56	7
DNAJB4	Physical association	Medium	0.56	4
EDRF1	Physical association	Medium	0.56	6
EIF2S2	Physical association	Medium	0.56	13
ELL2	Physical association	Medium	0.56	16
EML3	Physical association	Medium	0.56	5
ENKUR	Physical association	Medium	0.56	9
EXTL3	Physical association	Medium	0.56	1
FARSB	Physical association	Medium	0.56	3
FEZ2	Physical association	Medium	0.56	12
FKBP2	Physical association	Medium	0.56	5
FNDC9	Physical association	Medium	0.56	76
FOXN4	Physical association	Medium	0.56	3
FTL	Physical association	Medium	0.56	13
GORASP2	Physical association	Medium	0.56	111
H2BC9	Physical association	Medium	0.56	2
HOXC4	Physical association	Medium	0.56	22
HSFY1	Physical association	Medium	0.56	16
HSFY2	Physical association	Medium	0.56	16
HSPA1A	Physical association	Medium	0.56	7
ITGB1BP1	Physical association	Medium	0.56	7
KLHL17	Physical association	Medium	0.56	2
KLHL20	Physical association	Medium	0.56	31
KRTAP12-4	Physical association	Medium	0.56	41
KRTAP13-3	Physical association	Medium	0.56	58
KRTAP19-1	Physical association	Medium	0.56	36
KRTAP8-1	Physical association	Medium	0.56	76
KRTAP9-2	Physical association	Medium	0.56	123
LCA5L	Physical association	Medium	0.56	14
LDHAL6B	Physical association	Medium	0.56	17
LGALS9C	Physical association	Medium	0.56	23
LHX6	Physical association	Medium	0.56	18
LNX1	Physical association	Medium	0.56	333
LNX2	Physical association	Medium	0.56	63
MGARP	Physical association	Medium	0.56	14
MKNK1	Physical association	Medium	0.56	6
MOCS3	Physical association	Medium	0.56	3
MPND	Physical association	Medium	0.56	15
MRFAP1	Physical association	Medium	0.56	34
MRFAP1L1	Physical association	Medium	0.56	46
NEBL	Physical association	Medium	0.56	28
NEK8	Physical association	Medium	0.56	12
NFX1	Physical association	Medium	0.56	5
NHSL2	Physical association	Medium	0.56	19
NME4	Physical association	Medium	0.56	43
NME5	Physical association	Medium	0.56	5
NSDHL	Physical association	Medium	0.56	3
NUP43	Physical association	Medium	0.56	11
OGDH	Physical association	Medium	0.56	2
OTUB1	Physical association	Medium	0.56	43
PACS1	Physical association	Medium	0.56	8
PCMTD2	Physical association	Medium	0.56	8
PDLIM5	Physical association	Medium	0.56	9
PDZK1IP1	Physical association	Medium	0.56	71
PES1	Physical association	Medium	0.56	4
PIK3CA	Physical association	Medium	0.56	10
PIWIL1	Physical association	Medium	0.56	5
PLA2G10	Physical association	Medium	0.56	40
PLEKHG7	Physical association	Medium	0.56	18
POGZ	Physical association	Medium	0.56	58
POLR1H	Physical association	Medium	0.56	3
PQBP1	Physical association	Medium	0.56	9
PRKACA	Physical association	Medium	0.56	41
PRPF8	Physical association	Medium	0.56	19
PRR20C	Physical association	Medium	0.56	20
PRR20D	Physical association	Medium	0.56	55
PSMA1	Physical association	Medium	0.56	135
PSMB4	Physical association	Medium	0.56	31
RAD18	Physical association	Medium	0.56	12
RAD23A	Physical association	Medium	0.56	41
RAD54B	Physical association	Medium	0.56	3
RBBP4	Physical association	Medium	0.56	36
RBCK1	Physical association	Medium	0.56	21
REL	Physical association	Medium	0.56	141
RHEBL1	Physical association	Medium	0.56	7
RMND5A	Physical association	Medium	0.56	18
RNF112	Physical association	Medium	0.56	18
RNF139	Physical association	Medium	0.56	2
RNF183	Physical association	Medium	0.56	30
RNF2	Physical association	Medium	0.56	33
RPL10	Physical association	Medium	0.56	3
RPL15	Physical association	Medium	0.56	6
RPL18	Physical association	Medium	0.56	5
RPL19	Physical association	Medium	0.56	5
RPL22	Physical association	Medium	0.56	16
RPS19	Physical association	Medium	0.56	6
RPS5	Physical association	Medium	0.56	4
RYBP	Physical association	Medium	0.56	44
SAR1A	Physical association	Medium	0.56	65
SDCBP	Physical association	Medium	0.56	240
SERPINH1	Physical association	Medium	0.56	27
SF3A3	Physical association	Medium	0.56	7
SF3B3	Physical association	Medium	0.56	9
SKIC8	Physical association	Medium	0.56	30
SMARCD1	Physical association	Medium	0.56	104
SNAP29	Physical association	Medium	0.56	25
SNRNP40	Physical association	Medium	0.56	9
SNRPB	Physical association	Medium	0.56	15
SNRPD2	Physical association	Medium	0.56	14
SNRPD3	Physical association	Medium	0.56	9
SORCS3	Physical association	Medium	0.56	2
SOX14	Physical association	Medium	0.56	13
SOX3	Physical association	Medium	0.56	3
SPATA2L	Physical association	Medium	0.56	16
STAMBP	Physical association	Medium	0.56	21
SUMO3	Physical association	Medium	0.56	13
TBX15	Physical association	Medium	0.56	10
TBX22	Physical association	Medium	0.56	10
TGFBR2	Physical association	Medium	0.56	54
TLE5	Physical association	Medium	0.56	105
TNFAIP1	Physical association	Medium	0.56	31
TRIM23	Physical association	Medium	0.56	142
TRIM9	Physical association	Medium	0.56	18
TWIST2	Physical association	Medium	0.56	10
UBAC1	Physical association	Medium	0.56	24
UBE2V1	Physical association	Medium	0.56	23
UBOX5	Physical association	Medium	0.56	4
USP30	Physical association	Medium	0.56	1
USP46	Physical association	Medium	0.56	5
VCP	Physical association	Medium	0.56	48
VPS4B	Physical association	Medium	0.56	6
WDR83	Physical association	Medium	0.56	30
ZMAT2	Physical association	Medium	0.56	44
ZNF366	Physical association	Medium	0.56	22
OTX2	Physical association	Medium	0.55	1
GSPT1	Physical association	Medium	0.55	2
SF1	Physical association	Medium	0.55	14
ATXN2	Physical association	Medium	0.51	10
CCNK	Physical association	Medium	0.51	8
CPSF7	Physical association	Medium	0.51	11
DAZAP2	Physical association	Medium	0.51	124
IST1	Physical association	Medium	0.51	4
PLEKHA5	Physical association	Medium	0.51	4
PRRC2A	Physical association	Medium	0.51	3
RBFOX1	Physical association	Medium	0.51	10
SIX5	Physical association	Medium	0.51	1
TBC1D5	Physical association	Medium	0.51	10
USP54	Physical association	Medium	0.51	3
YY1AP1	Physical association	Medium	0.51	4
METTL17	Physical association	Medium	0.49	11
POM121	Physical association	Medium	0.49	7
Show allShow less

METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
ATXN1 is not a metabolic protein