Protein interactions for TRIP6 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TRIP6
Gene descriptionⁱ Full gene name according to HGNC.	Thyroid hormone receptor interactor 6
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Epithelium - Extracellular exosomes (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.18
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Plasma membrane, Focal adhesion sites, Cytosol
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Epithelium - Extracellular exosomes

Field

Cluster

Pathway

Number of interactions:

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
NCK2	Physical association	High	0.83	113
AQP1	Physical association	High	0.78	106
CATSPER1	Physical association	High	0.78	95
METTL17	Physical association	High	0.74	11
FRS3	Physical association	High	0.72	77
HOXA9	Physical association	High	0.68	3
ABI2	Physical association	High	0.67	49
ATXN1	Physical association	High	0.67	271
BYSL	Physical association	High	0.67	119
CTAG2	Physical association	High	0.67	1
GSE1	Physical association	High	0.67	15
OIP5	Physical association	High	0.67	113
SNAI1	Physical association	High	0.67	29
TEKT4	Physical association	High	0.67	80
PPP1R16A	Physical association	High	0.62	35
SCRIB	Direct interaction	Medium	0.56	28
ATP5PO	Physical association	Medium	0.56	18
AXIN1	Physical association	Medium	0.56	40
BAG3	Physical association	Medium	0.56	58
BEX2	Physical association	Medium	0.56	67
C11orf87	Physical association	Medium	0.56	18
CCDC120	Physical association	Medium	0.56	90
CCDC24	Physical association	Medium	0.56	28
CNTF	Physical association	Medium	0.56	14
CRYBA4	Physical association	Medium	0.56	10
DMRT3	Physical association	Medium	0.56	65
DTX2	Physical association	Medium	0.56	95
EFHC1	Physical association	Medium	0.56	61
EPDR1	Physical association	Medium	0.56	10
FAM222B	Physical association	Medium	0.56	25
FARS2	Physical association	Medium	0.56	56
FASLG	Physical association	Medium	0.56	28
FOXD4L1	Physical association	Medium	0.56	17
GNAI2	Physical association	Medium	0.56	10
GPS2	Physical association	Medium	0.56	31
HOXB9	Physical association	Medium	0.56	42
HOXC8	Physical association	Medium	0.56	74
HTT	Physical association	Medium	0.56	665
INCA1	Physical association	Medium	0.56	204
IP6K3	Physical association	Medium	0.56	13
KCTD9	Physical association	Medium	0.56	77
KIR2DL4	Physical association	Medium	0.56	6
KLK15	Physical association	Medium	0.56	2
KPRP	Physical association	Medium	0.56	80
KRTAP26-1	Physical association	Medium	0.56	73
LMO2	Physical association	Medium	0.56	61
LNX1	Physical association	Medium	0.56	333
MAPKBP1	Physical association	Medium	0.56	48
MEMO1	Physical association	Medium	0.56	16
MIEN1	Physical association	Medium	0.56	9
MIIP	Physical association	Medium	0.56	24
MISP	Physical association	Medium	0.56	44
MSRB3	Physical association	Medium	0.56	4
NEDD9	Physical association	Medium	0.56	12
OTX1	Physical association	Medium	0.56	118
PDGFRB	Physical association	Medium	0.56	21
PIGS	Physical association	Medium	0.56	11
PIN1	Physical association	Medium	0.56	112
PRKAA1	Physical association	Medium	0.56	33
PRKAA2	Physical association	Medium	0.56	78
PTPN14	Physical association	Medium	0.56	2
RAD23A	Physical association	Medium	0.56	41
RANBP3L	Physical association	Medium	0.56	3
RFX3	Physical association	Medium	0.56	8
RHOA	Physical association	Medium	0.56	20
SAXO1	Physical association	Medium	0.56	39
SCAND1	Physical association	Medium	0.56	40
SHISA6	Physical association	Medium	0.56	20
SLC25A6	Physical association	Medium	0.56	12
SMG9	Physical association	Medium	0.56	32
STK16	Physical association	Medium	0.56	66
TBC1D22B	Physical association	Medium	0.56	46
TCAF1	Physical association	Medium	0.56	9
TIE1	Physical association	Medium	0.56	7
TRAF3IP2	Physical association	Medium	0.56	5
TRAPPC2L	Physical association	Medium	0.56	6
TRIM29	Physical association	Medium	0.56	13
TSGA10IP	Physical association	Medium	0.56	83
TSSK3	Physical association	Medium	0.56	51
TTLL10	Physical association	Medium	0.56	10
TXN2	Physical association	Medium	0.56	60
USP2	Physical association	Medium	0.56	78
VASN	Physical association	Medium	0.56	42
ZIC1	Physical association	Medium	0.56	55
ZNF541	Physical association	Medium	0.56	2
ZNF580	Physical association	Medium	0.56	15
ZNF581	Physical association	Medium	0.56	82
ZNF785	Physical association	Medium	0.56	13
VCL	Physical association	Medium	0.55	4
ATN1	Physical association	Medium	0.51	9
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
TRIP6 is not a metabolic protein