Protein interactions for GORASP2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GORASP2
Gene descriptionⁱ Full gene name according to HGNC.	Golgi reassembly stacking protein 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Protein processing (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.11
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Golgi apparatus
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Non-specific - Protein processing

Field

Cluster

Pathway

Number of interactions:

111

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
ACY3	Physical association	High	0.87	15
CRYAA	Physical association	High	0.84	72
CBLB	Physical association	High	0.83	25
DPYSL2	Physical association	High	0.83	7
EIF2B1	Physical association	High	0.83	13
RPIA	Physical association	High	0.83	15
TRAF2	Physical association	High	0.83	237
PCBD1	Physical association	High	0.8	12
PRPS1	Physical association	High	0.8	79
GOLGA2	Physical association	High	0.8	349
C1orf94	Physical association	High	0.78	69
DCTD	Physical association	High	0.78	8
DMC1	Physical association	High	0.78	10
DUSP21	Physical association	High	0.78	15
KCTD9	Physical association	High	0.78	77
LONRF1	Physical association	High	0.78	77
ODC1	Physical association	High	0.78	3
PNMA5	Physical association	High	0.78	53
TRAF1	Physical association	High	0.78	166
TXLNA	Physical association	High	0.78	76
NQO2	Physical association	High	0.74	5
PRDX3	Physical association	High	0.74	4
CDC23	Physical association	High	0.72	69
GABPB2	Physical association	High	0.72	7
MAP1LC3B	Physical association	High	0.72	51
SCAND1	Physical association	High	0.72	40
TRIM38	Physical association	High	0.72	17
ARL6IP1	Physical association	High	0.67	60
BEND5	Physical association	High	0.67	15
CCDC153	Physical association	High	0.67	4
PDE9A	Physical association	High	0.67	14
STOX1	Physical association	High	0.67	2
TCF4	Physical association	High	0.67	124
TEKT3	Physical association	High	0.67	28
TLE5	Physical association	High	0.67	105
TRAF4	Physical association	High	0.67	73
ZBTB14	Physical association	High	0.67	54
CFTR	Direct interaction	High	0.65	94
GNG7	Physical association	High	0.6	1
TAGLN	Physical association	High	0.6	2
AAMDC	Physical association	Medium	0.56	6
ALKBH4	Physical association	Medium	0.56	8
APIP	Physical association	Medium	0.56	16
ARHGEF15	Physical association	Medium	0.56	2
ASMTL	Physical association	Medium	0.56	8
ATP6V1G1	Physical association	Medium	0.56	8
ATXN1	Physical association	Medium	0.56	271
ATXN3	Physical association	Medium	0.56	74
BTBD3	Physical association	Medium	0.56	6
CARHSP1	Physical association	Medium	0.56	11
CBY1	Physical association	Medium	0.56	27
CCDC90B	Physical association	Medium	0.56	6
CDA	Physical association	Medium	0.56	14
CDK18	Physical association	Medium	0.56	45
CDKN2D	Physical association	Medium	0.56	41
CEP76	Physical association	Medium	0.56	79
CGGBP1	Physical association	Medium	0.56	13
CHMP1A	Physical association	Medium	0.56	14
CNTNAP2	Physical association	Medium	0.56	4
CRYAB	Physical association	Medium	0.56	18
DNAJB13	Physical association	Medium	0.56	9
DUSP4	Physical association	Medium	0.56	10
ECHDC1	Physical association	Medium	0.56	1
EMILIN3	Physical association	Medium	0.56	6
ENOX1	Physical association	Medium	0.56	5
ETHE1	Physical association	Medium	0.56	3
FIG4	Physical association	Medium	0.56	2
GNGT1	Physical association	Medium	0.56	3
GSTZ1	Physical association	Medium	0.56	6
GTF2IRD1	Physical association	Medium	0.56	8
HOXC5	Physical association	Medium	0.56	9
HSBP1	Physical association	Medium	0.56	15
HSPB11	Physical association	Medium	0.56	16
KCTD13	Physical association	Medium	0.56	22
KIFC3	Physical association	Medium	0.56	70
KRTAP5-11	Physical association	Medium	0.56	49
MIEN1	Physical association	Medium	0.56	9
MORN2	Physical association	Medium	0.56	1
MPLKIP	Physical association	Medium	0.56	3
MSC	Physical association	Medium	0.56	3
NHSL2	Physical association	Medium	0.56	19
NMNAT1	Physical association	Medium	0.56	11
NUDT5	Physical association	Medium	0.56	3
PRKAB2	Physical association	Medium	0.56	126
PSMA3	Physical association	Medium	0.56	51
PSMD2	Physical association	Medium	0.56	25
PSMD6	Physical association	Medium	0.56	17
RAB27B	Physical association	Medium	0.56	7
RAB39A	Physical association	Medium	0.56	5
RBM46	Physical association	Medium	0.56	7
RGL2	Physical association	Medium	0.56	6
SEPTIN1	Physical association	Medium	0.56	17
SEPTIN14	Physical association	Medium	0.56	4
SHMT1	Physical association	Medium	0.56	6
TP53RK	Physical association	Medium	0.56	6
TPH1	Physical association	Medium	0.56	3
TRAF5	Physical association	Medium	0.56	35
TSEN15	Physical association	Medium	0.56	21
TSN	Physical association	Medium	0.56	10
TTC19	Physical association	Medium	0.56	33
UBE2Z	Physical association	Medium	0.56	10
UBL3	Physical association	Medium	0.56	4
VPS37B	Physical association	Medium	0.56	22
VPS52	Physical association	Medium	0.56	83
ZBED1	Physical association	Medium	0.56	33
ZMYND19	Physical association	Medium	0.56	39
ZNF148	Physical association	Medium	0.56	7
NUP62	Physical association	Medium	0.55	61
RGS3	Physical association	Medium	0.55	3
ZMAT1	Physical association	Medium	0.55	1
MMP14	Physical association	Medium	0.46	17
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
GORASP2 is not a metabolic protein