Protein interactions for HSP90AB1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	HSP90AB1
Gene descriptionⁱ Full gene name according to HGNC.	Heat shock protein 90 alpha family class B member 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Cancer-related genes Plasma proteins Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Skeletal muscle - Muscle contraction (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.13
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Cytosol
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Skeletal muscle - Muscle contraction

Field

Cluster

Pathway

Number of interactions:

137

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
EGFR	Physical association	High	0.89	270
CDC37	Physical association	High	0.89	124
PPP5C	Direct interaction	High	0.87	15
RAF1	Physical association	High	0.86	40
FKBP5	Direct interaction	High	0.85	11
AIP	Direct interaction	High	0.83	5
ARAF	Physical association	High	0.81	14
CHORDC1	Physical association	High	0.8	3
FKBP4	Direct interaction	High	0.79	10
ERBB2	Physical association	High	0.79	49
AURKB	Physical association	High	0.78	17
CDK4	Physical association	High	0.78	24
MAP3K14	Physical association	High	0.76	39
PTGES3	Direct interaction	High	0.74	6
CDC37L1	Physical association	High	0.74	3
STUB1	Direct interaction	High	0.74	54
FYN	Physical association	High	0.72	46
STK11	Physical association	High	0.72	15
AHSA1	Direct interaction	High	0.7	4
STIP1	Direct interaction	High	0.69	19
TTC4	Direct interaction	High	0.68	5
BLK	Physical association	High	0.67	22
BRAF	Physical association	High	0.67	14
CDK9	Physical association	High	0.67	13
FGFR1	Physical association	High	0.67	13
HCK	Physical association	High	0.67	17
IKBKG	Physical association	High	0.67	57
ITK	Physical association	High	0.67	4
MAP2K5	Physical association	High	0.67	10
MAP4K1	Physical association	High	0.67	9
MYLK4	Physical association	High	0.67	1
PDIK1L	Physical association	High	0.67	5
PSKH2	Physical association	High	0.67	3
RPS6KA1	Physical association	High	0.67	7
STYK1	Physical association	High	0.67	2
TSSK6	Physical association	High	0.67	3
FGFR3	Physical association	High	0.67	192
CHEK1	Physical association	High	0.66	7
MAP3K8	Physical association	High	0.66	5
GSK3A	Physical association	High	0.65	12
CDK10	Physical association	High	0.64	3
CILK1	Physical association	High	0.64	3
CUL3	Physical association	High	0.64	36
DDR2	Physical association	High	0.64	6
FGR	Physical association	High	0.64	2
FLT4	Physical association	High	0.64	2
KLHL38	Physical association	High	0.64	72
LCK	Physical association	High	0.64	29
LIMK2	Physical association	High	0.64	2
MAPK4	Physical association	High	0.64	1
PRKCE	Physical association	High	0.64	8
PRKX	Physical association	High	0.64	4
PSKH1	Physical association	High	0.64	1
TESK2	Physical association	High	0.64	1
INSRR	Physical association	High	0.6	2
NTRK1	Physical association	High	0.6	6
IKBKE	Physical association	Medium	0.59	19
RIPK1	Physical association	Medium	0.59	17
TBK1	Physical association	Medium	0.59	30
AGO1	Physical association	Medium	0.56	9
AKT1	Physical association	Medium	0.56	58
AXL	Physical association	Medium	0.56	3
BMX	Physical association	Medium	0.56	4
CAMK2A	Physical association	Medium	0.56	52
CDK3	Physical association	Medium	0.56	19
CDK7	Physical association	Medium	0.56	6
CLK3	Physical association	Medium	0.56	34
CSNK1A1	Physical association	Medium	0.56	18
CUL1	Physical association	Medium	0.56	31
CUL2	Physical association	Medium	0.56	13
CUL4A	Physical association	Medium	0.56	12
CUL4B	Physical association	Medium	0.56	12
DYRK1B	Physical association	Medium	0.56	10
DYRK4	Physical association	Medium	0.56	4
EIF2AK1	Physical association	Medium	0.56	2
ERBB3	Physical association	Medium	0.56	19
FBXL2	Physical association	Medium	0.56	3
FBXO24	Physical association	Medium	0.56	2
FBXW2	Physical association	Medium	0.56	9
FER	Physical association	Medium	0.56	3
GRK6	Physical association	Medium	0.56	2
GRK7	Physical association	Medium	0.56	1
HIPK4	Physical association	Medium	0.56	2
ILK	Physical association	Medium	0.56	18
LYN	Physical association	Medium	0.56	29
MAP2K7	Physical association	Medium	0.56	4
MAPK15	Physical association	Medium	0.56	2
MOS	Physical association	Medium	0.56	46
MYLK2	Physical association	Medium	0.56	4
MYO3B	Physical association	Medium	0.56	1
NEK11	Physical association	Medium	0.56	2
NEK8	Physical association	Medium	0.56	12
PRKAA1	Physical association	Medium	0.56	33
PRKACB	Physical association	Medium	0.56	5
PRKCG	Physical association	Medium	0.56	5
PRKN	Physical association	Medium	0.56	11
PTK6	Physical association	Medium	0.56	22
RPS6KA3	Physical association	Medium	0.56	6
SGK2	Physical association	Medium	0.56	1
STK32C	Physical association	Medium	0.56	2
TNK2	Physical association	Medium	0.56	12
TSSK1B	Physical association	Medium	0.56	5
TSSK2	Physical association	Medium	0.56	5
TYRO3	Physical association	Medium	0.56	13
YES1	Physical association	Medium	0.56	44
MAGEB6	Physical association	Medium	0.56	12
FAM162A	Physical association	Medium	0.54	2
IKBKB	Physical association	Medium	0.54	20
TRAF2	Physical association	Medium	0.54	237
ACVR1B	Physical association	Medium	0.52	3
AKT2	Physical association	Medium	0.52	4
ALK	Physical association	Medium	0.52	5
AMHR2	Physical association	Medium	0.52	2
BTK	Physical association	Medium	0.52	12
CAMK2G	Physical association	Medium	0.52	2
CDK14	Physical association	Medium	0.52	8
CDK15	Physical association	Medium	0.52	2
CDK6	Physical association	Medium	0.52	15
CSNK1E	Physical association	Medium	0.52	16
EPHA2	Physical association	Medium	0.52	11
ERBB4	Physical association	Medium	0.52	14
HASPIN	Physical association	Medium	0.52	3
MAP3K9	Physical association	Medium	0.52	4
MATK	Physical association	Medium	0.52	6
MUSK	Physical association	Medium	0.52	2
NEK9	Physical association	Medium	0.52	12
NR1I2	Physical association	Medium	0.52	2
POGK	Physical association	Medium	0.52	1
PRKCZ	Physical association	Medium	0.52	14
PRKD1	Physical association	Medium	0.52	6
RGS6	Physical association	Medium	0.52	1
ROR2	Physical association	Medium	0.52	24
STK38	Physical association	Medium	0.52	8
TYK2	Physical association	Medium	0.52	13
AMPD3	Physical association	Medium	0.5	1
RPL11	Physical association	Medium	0.5	8
UNC45B	Physical association	Medium	0.5	1
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
HSP90AB1 is not a metabolic protein