Cell line - JMJD6 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	JMJD6
Gene descriptionⁱ Full gene name according to HGNC.	Jumonji domain containing 6, arginine demethylase and lysine hydroxylase
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression based on cell line data from the DepMap portal and cell line data generated within the Human Protein Atlas project.
Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across cell lines. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Breast cancer - Unknown function (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from cancer cell lines in the Human Protein Atlas grouped according to type of cancer. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cancer specificity
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.09
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from cancer cell lines in the Human Protein Atlas grouped according to type of cancer. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

CELL LINESⁱ RNA expression data as normalized transcript per million (nTPM) values of cancer cell lines.The analyzed cell lines are grouped according to cancer type. Detailed information about the groups is revealed by hovering over the corresponding bar in the chart. More information and cell line data can be found in the Cell line section.
Cell line categories Alphabetical Expression RNA specificity:Low cancer specificity

EXPRESSION CLUSTERING & CORRELATIONⁱ

JMJD6 is part of cluster 27 Breast cancer - Unknown function with confidenceⁱ 1
687 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
NPLOC4	NPL4 homolog, ubiquitin recognition factor	0.6195	27
PSMC5	Proteasome 26S subunit, ATPase 5	0.5429	27
FAM104A	Family with sequence similarity 104 member A	0.5349	27
SRP68	Signal recognition particle 68	0.5208	27
CCDC137	Coiled-coil domain containing 137	0.5078	27
GPS1	G protein pathway suppressor 1	0.4913	27
WBP2	WW domain binding protein 2	0.4882	27
ARHGDIA	Rho GDP dissociation inhibitor alpha	0.4847	27
SAP30BP	SAP30 binding protein	0.4786	27
PGK1	Phosphoglycerate kinase 1	0.4736	15
COG1	Component of oligomeric golgi complex 1	0.4736	27
TACO1	Translational activator of cytochrome c oxidase I	0.4721	27
HGS	Hepatocyte growth factor-regulated tyrosine kinase substrate	0.4681	27
P4HB	Prolyl 4-hydroxylase subunit beta	0.4606	63
WDR45B	WD repeat domain 45B	0.4538	27

CELL LINE DATA

Alphabetical Expression Adrenocortical cancer (n=1)
Alphabetical Expression Bile duct cancer (n=7)
Alphabetical Expression Bladder cancer (n=26)
Alphabetical Expression Bone cancer (n=21)
Alphabetical Expression Brain cancer (n=80)
Alphabetical Expression Breast cancer (n=62)
Alphabetical Expression Cervical cancer (n=8)
Alphabetical Expression Colorectal cancer (n=63)
Alphabetical Expression Esophageal cancer (n=27)
Alphabetical Expression Gallbladder cancer (n=1)
Alphabetical Expression Gastric cancer (n=42)
Alphabetical Expression Head and Neck cancer (n=38)
Alphabetical Expression Kidney cancer (n=35)
Alphabetical Expression Leukemia (n=93)
Alphabetical Expression Liver cancer (n=24)
Alphabetical Expression Lung cancer (n=232)
Alphabetical Expression Lymphoma (n=76)
Alphabetical Expression Myeloma (n=34)
Alphabetical Expression Neuroblastoma (n=17)
Alphabetical Expression Non-cancerous (n=63)
Alphabetical Expression Ovarian cancer (n=59)
Alphabetical Expression Pancreatic cancer (n=46)
Alphabetical Expression Prostate cancer (n=8)
Alphabetical Expression Rhabdoid (n=14)
Alphabetical Expression Sarcoma (n=15)
Alphabetical Expression Skin cancer (n=62)
Alphabetical Expression Testis cancer (n=1)
Alphabetical Expression Thyroid cancer (n=11)
Alphabetical Expression Uncategorized (n=11)
Alphabetical Expression Uterine cancer (n=29)