GENERAL INFORMATIONi
Gene namei HSP90AB1
Synonyms HSPC2, HSPCB
Gene descriptioni Heat shock protein 90 alpha family class B member 1
Protein classi Cancer-related genes
Plasma proteins
Transporters
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 6
Cytoband p21.1
Chromosome location (bp) 44246166 - 44253888
Number of transcriptsi 4
Ensembl ENSG00000096384 (version 109)
Entrez gene 3326
HGNC HGNC:5258
UniProt P08238 (UniProt - Evidence at protein level)
neXtProt NX_P08238
GeneCards HSP90AB1
Antibodypedia HSP90AB1 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function 1, 2. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle 3, 4. Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression 5. Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation 6. Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery 7. Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription 8. Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 9. show less
Molecular function (UniProt)i Chaperone
Biological process (UniProt)i Stress response
Ligand (UniProt)i ATP-binding, Nucleotide-binding
Gene summary (Entrez)i This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
HSP90AB1-201
ENSP00000325875
ENST00000353801
P08238
[Direct mapping] Heat shock protein HSP 90-beta
Show all
A0A024RD80
[Target identity:100%; Query identity:100%] Heat shock protein 90kDa alpha (Cytosolic), class B member 1, isoform CRA_a
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006457 [protein folding]
GO:0006986 [response to unfolded protein]
GO:0007004 [telomere maintenance via telomerase]
GO:0008180 [COP9 signalosome]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016887 [ATP hydrolysis activity]
GO:0019062 [virion attachment to host cell]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0021955 [central nervous system neuron axonogenesis]
GO:0023026 [MHC class II protein complex binding]
GO:0030010 [establishment of cell polarity]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway]
GO:0030911 [TPR domain binding]
GO:0031072 [heat shock protein binding]
GO:0031396 [regulation of protein ubiquitination]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0032516 [positive regulation of phosphoprotein phosphatase activity]
GO:0032880 [regulation of protein localization]
GO:0032991 [protein-containing complex]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034605 [cellular response to heat]
GO:0034751 [aryl hydrocarbon receptor complex]
GO:0034774 [secretory granule lumen]
GO:0042277 [peptide binding]
GO:0042470 [melanosome]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042826 [histone deacetylase binding]
GO:0043008 [ATP-dependent protein binding]
GO:0043025 [neuronal cell body]
GO:0044294 [dendritic growth cone]
GO:0044295 [axonal growth cone]
GO:0045296 [cadherin binding]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045597 [positive regulation of cell differentiation]
GO:0046983 [protein dimerization activity]
GO:0048156 [tau protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048675 [axon extension]
GO:0050821 [protein stabilization]
GO:0051082 [unfolded protein binding]
GO:0051131 [chaperone-mediated protein complex assembly]
GO:0051248 [negative regulation of protein metabolic process]
GO:0051726 [regulation of cell cycle]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0051973 [positive regulation of telomerase activity]
GO:0070062 [extracellular exosome]
GO:0070182 [DNA polymerase binding]
GO:0097435 [supramolecular fiber organization]
GO:0097718 [disordered domain specific binding]
GO:0120293 [dynein axonemal particle]
GO:0140662 [ATP-dependent protein folding chaperone]
GO:1901389 [negative regulation of transforming growth factor beta activation]
GO:1901799 [negative regulation of proteasomal protein catabolic process]
GO:1902949 [positive regulation of tau-protein kinase activity]
GO:1904031 [positive regulation of cyclin-dependent protein kinase activity]
GO:1904813 [ficolin-1-rich granule lumen]
GO:1905323 [telomerase holoenzyme complex assembly]
GO:1990226 [histone methyltransferase binding]
GO:1990565 [HSP90-CDC37 chaperone complex]
GO:2000010 [positive regulation of protein localization to cell surface]
Show all
 724 aa
83.3 kDa 		No 0
HSP90AB1-202
ENSP00000360609
ENST00000371554
P08238
[Direct mapping] Heat shock protein HSP 90-beta
Show all
A0A024RD80
[Target identity:100%; Query identity:100%] Heat shock protein 90kDa alpha (Cytosolic), class B member 1, isoform CRA_a
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006457 [protein folding]
GO:0006986 [response to unfolded protein]
GO:0007004 [telomere maintenance via telomerase]
GO:0008180 [COP9 signalosome]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016887 [ATP hydrolysis activity]
GO:0019062 [virion attachment to host cell]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0021955 [central nervous system neuron axonogenesis]
GO:0023026 [MHC class II protein complex binding]
GO:0030010 [establishment of cell polarity]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway]
GO:0030911 [TPR domain binding]
GO:0031072 [heat shock protein binding]
GO:0031396 [regulation of protein ubiquitination]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0032516 [positive regulation of phosphoprotein phosphatase activity]
GO:0032880 [regulation of protein localization]
GO:0032991 [protein-containing complex]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034605 [cellular response to heat]
GO:0034751 [aryl hydrocarbon receptor complex]
GO:0034774 [secretory granule lumen]
GO:0042277 [peptide binding]
GO:0042470 [melanosome]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042826 [histone deacetylase binding]
GO:0043008 [ATP-dependent protein binding]
GO:0043025 [neuronal cell body]
GO:0044294 [dendritic growth cone]
GO:0044295 [axonal growth cone]
GO:0045296 [cadherin binding]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045597 [positive regulation of cell differentiation]
GO:0046983 [protein dimerization activity]
GO:0048156 [tau protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048675 [axon extension]
GO:0050821 [protein stabilization]
GO:0051082 [unfolded protein binding]
GO:0051131 [chaperone-mediated protein complex assembly]
GO:0051248 [negative regulation of protein metabolic process]
GO:0051726 [regulation of cell cycle]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0051973 [positive regulation of telomerase activity]
GO:0070062 [extracellular exosome]
GO:0070182 [DNA polymerase binding]
GO:0097435 [supramolecular fiber organization]
GO:0097718 [disordered domain specific binding]
GO:0120293 [dynein axonemal particle]
GO:0140662 [ATP-dependent protein folding chaperone]
GO:1901389 [negative regulation of transforming growth factor beta activation]
GO:1901799 [negative regulation of proteasomal protein catabolic process]
GO:1902949 [positive regulation of tau-protein kinase activity]
GO:1904031 [positive regulation of cyclin-dependent protein kinase activity]
GO:1904813 [ficolin-1-rich granule lumen]
GO:1905323 [telomerase holoenzyme complex assembly]
GO:1990226 [histone methyltransferase binding]
GO:1990565 [HSP90-CDC37 chaperone complex]
GO:2000010 [positive regulation of protein localization to cell surface]
Show all
 724 aa
83.3 kDa 		No 0
HSP90AB1-203
ENSP00000360709
ENST00000371646
P08238
[Direct mapping] Heat shock protein HSP 90-beta
Show all
A0A024RD80
[Target identity:100%; Query identity:100%] Heat shock protein 90kDa alpha (Cytosolic), class B member 1, isoform CRA_a
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001890 [placenta development]
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006457 [protein folding]
GO:0006986 [response to unfolded protein]
GO:0007004 [telomere maintenance via telomerase]
GO:0008180 [COP9 signalosome]
GO:0009986 [cell surface]
GO:0010033 [response to organic substance]
GO:0016020 [membrane]
GO:0016887 [ATP hydrolysis activity]
GO:0019062 [virion attachment to host cell]
GO:0019887 [protein kinase regulator activity]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0019901 [protein kinase binding]
GO:0021955 [central nervous system neuron axonogenesis]
GO:0023026 [MHC class II protein complex binding]
GO:0030010 [establishment of cell polarity]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway]
GO:0030911 [TPR domain binding]
GO:0031072 [heat shock protein binding]
GO:0031396 [regulation of protein ubiquitination]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0032516 [positive regulation of phosphoprotein phosphatase activity]
GO:0032880 [regulation of protein localization]
GO:0032991 [protein-containing complex]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034605 [cellular response to heat]
GO:0034751 [aryl hydrocarbon receptor complex]
GO:0034774 [secretory granule lumen]
GO:0042277 [peptide binding]
GO:0042470 [melanosome]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042826 [histone deacetylase binding]
GO:0043008 [ATP-dependent protein binding]
GO:0043025 [neuronal cell body]
GO:0043066 [negative regulation of apoptotic process]
GO:0044183 [protein folding chaperone]
GO:0044294 [dendritic growth cone]
GO:0044295 [axonal growth cone]
GO:0045296 [cadherin binding]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045597 [positive regulation of cell differentiation]
GO:0046983 [protein dimerization activity]
GO:0048156 [tau protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048675 [axon extension]
GO:0050821 [protein stabilization]
GO:0051082 [unfolded protein binding]
GO:0051131 [chaperone-mediated protein complex assembly]
GO:0051248 [negative regulation of protein metabolic process]
GO:0051726 [regulation of cell cycle]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0051973 [positive regulation of telomerase activity]
GO:0070062 [extracellular exosome]
GO:0070182 [DNA polymerase binding]
GO:0071353 [cellular response to interleukin-4]
GO:0097435 [supramolecular fiber organization]
GO:0097718 [disordered domain specific binding]
GO:0120293 [dynein axonemal particle]
GO:0140662 [ATP-dependent protein folding chaperone]
GO:1901389 [negative regulation of transforming growth factor beta activation]
GO:1901799 [negative regulation of proteasomal protein catabolic process]
GO:1902949 [positive regulation of tau-protein kinase activity]
GO:1904031 [positive regulation of cyclin-dependent protein kinase activity]
GO:1904813 [ficolin-1-rich granule lumen]
GO:1905323 [telomerase holoenzyme complex assembly]
GO:1990226 [histone methyltransferase binding]
GO:1990565 [HSP90-CDC37 chaperone complex]
GO:2000010 [positive regulation of protein localization to cell surface]
Show all
 724 aa
83.3 kDa 		No 0
HSP90AB1-204
ENSP00000481908
ENST00000620073
P08238
[Direct mapping] Heat shock protein HSP 90-beta
Show all
A0A024RD80
[Target identity:100%; Query identity:100%] Heat shock protein 90kDa alpha (Cytosolic), class B member 1, isoform CRA_a
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006457 [protein folding]
GO:0006986 [response to unfolded protein]
GO:0007004 [telomere maintenance via telomerase]
GO:0008180 [COP9 signalosome]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016887 [ATP hydrolysis activity]
GO:0019062 [virion attachment to host cell]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0021955 [central nervous system neuron axonogenesis]
GO:0023026 [MHC class II protein complex binding]
GO:0030010 [establishment of cell polarity]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway]
GO:0030911 [TPR domain binding]
GO:0031072 [heat shock protein binding]
GO:0031396 [regulation of protein ubiquitination]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0032516 [positive regulation of phosphoprotein phosphatase activity]
GO:0032880 [regulation of protein localization]
GO:0032991 [protein-containing complex]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034605 [cellular response to heat]
GO:0034751 [aryl hydrocarbon receptor complex]
GO:0034774 [secretory granule lumen]
GO:0042277 [peptide binding]
GO:0042470 [melanosome]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042826 [histone deacetylase binding]
GO:0043008 [ATP-dependent protein binding]
GO:0043025 [neuronal cell body]
GO:0044294 [dendritic growth cone]
GO:0044295 [axonal growth cone]
GO:0045296 [cadherin binding]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045597 [positive regulation of cell differentiation]
GO:0046983 [protein dimerization activity]
GO:0048156 [tau protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048675 [axon extension]
GO:0050821 [protein stabilization]
GO:0051082 [unfolded protein binding]
GO:0051131 [chaperone-mediated protein complex assembly]
GO:0051248 [negative regulation of protein metabolic process]
GO:0051726 [regulation of cell cycle]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0051973 [positive regulation of telomerase activity]
GO:0070062 [extracellular exosome]
GO:0070182 [DNA polymerase binding]
GO:0097435 [supramolecular fiber organization]
GO:0097718 [disordered domain specific binding]
GO:0120293 [dynein axonemal particle]
GO:0140662 [ATP-dependent protein folding chaperone]
GO:1901389 [negative regulation of transforming growth factor beta activation]
GO:1901799 [negative regulation of proteasomal protein catabolic process]
GO:1902949 [positive regulation of tau-protein kinase activity]
GO:1904031 [positive regulation of cyclin-dependent protein kinase activity]
GO:1904813 [ficolin-1-rich granule lumen]
GO:1905323 [telomerase holoenzyme complex assembly]
GO:1990226 [histone methyltransferase binding]
GO:1990565 [HSP90-CDC37 chaperone complex]
GO:2000010 [positive regulation of protein localization to cell surface]
Show all
 724 aa
83.3 kDa 		No 0

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