Cell line - HCFC1R1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	HCFC1R1
Gene descriptionⁱ Full gene name according to HGNC.	Host cell factor C1 regulator 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression based on cell line data from the DepMap portal and cell line data generated within the Human Protein Atlas project.
Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across cell lines. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Transcription (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from cancer cell lines in the Human Protein Atlas grouped according to type of cancer. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cancer specificity
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.20
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from cancer cell lines in the Human Protein Atlas grouped according to type of cancer. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

CELL LINESⁱ RNA expression data as normalized transcript per million (nTPM) values of cancer cell lines.The analyzed cell lines are grouped according to cancer type. Detailed information about the groups is revealed by hovering over the corresponding bar in the chart. More information and cell line data can be found in the Cell line section.
Cell line categories Alphabetical Expression RNA specificity:Low cancer specificity

EXPRESSION CLUSTERING & CORRELATIONⁱ

HCFC1R1 is part of cluster 54 Non-specific - Transcription with confidenceⁱ 1
224 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
BCKDK	Branched chain keto acid dehydrogenase kinase	0.5789	54
THOC6	THO complex subunit 6	0.4679	54
PAX2	Paired box 2	0.4668	15
BIVM-ERCC5	BIVM-ERCC5 readthrough	0.4529	15
TSR3	TSR3 ribosome maturation factor	0.4374	54
BCL7C	BAF chromatin remodeling complex subunit BCL7C	0.4354	54
MRPL28	Mitochondrial ribosomal protein L28	0.4270	54
FUT11	Fucosyltransferase 11	0.4194	15
C10orf62	Chromosome 10 open reading frame 62	0.4179	15
AMDHD2	Amidohydrolase domain containing 2	0.4178	9
STUB1	STIP1 homology and U-box containing protein 1	0.4176	54
MVP	Major vault protein	0.4146	53
FAHD1	Fumarylacetoacetate hydrolase domain containing 1	0.4107	54
SRGAP1	SLIT-ROBO Rho GTPase activating protein 1	0.4087	15
TMEM219	Transmembrane protein 219	0.4003	54

CELL LINE DATA

Alphabetical Expression Adrenocortical cancer (n=1)
Alphabetical Expression Bile duct cancer (n=7)
Alphabetical Expression Bladder cancer (n=26)
Alphabetical Expression Bone cancer (n=21)
Alphabetical Expression Brain cancer (n=80)
Alphabetical Expression Breast cancer (n=62)
Alphabetical Expression Cervical cancer (n=8)
Alphabetical Expression Colorectal cancer (n=63)
Alphabetical Expression Esophageal cancer (n=27)
Alphabetical Expression Gallbladder cancer (n=1)
Alphabetical Expression Gastric cancer (n=42)
Alphabetical Expression Head and Neck cancer (n=38)
Alphabetical Expression Kidney cancer (n=35)
Alphabetical Expression Leukemia (n=93)
Alphabetical Expression Liver cancer (n=24)
Alphabetical Expression Lung cancer (n=232)
Alphabetical Expression Lymphoma (n=76)
Alphabetical Expression Myeloma (n=34)
Alphabetical Expression Neuroblastoma (n=17)
Alphabetical Expression Non-cancerous (n=63)
Alphabetical Expression Ovarian cancer (n=59)
Alphabetical Expression Pancreatic cancer (n=46)
Alphabetical Expression Prostate cancer (n=8)
Alphabetical Expression Rhabdoid (n=14)
Alphabetical Expression Sarcoma (n=15)
Alphabetical Expression Skin cancer (n=62)
Alphabetical Expression Testis cancer (n=1)
Alphabetical Expression Thyroid cancer (n=11)
Alphabetical Expression Uncategorized (n=11)
Alphabetical Expression Uterine cancer (n=29)