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On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.
Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.
If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.
h
m
l
n
Glial cells:
Not detected
Neuronal cells:
Not detected
RNA expressioni
A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.
The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.
Scroll down to view mRNA expression data in more detail.
Consensus:
23.0
nTPM
HPA Brain:
44.5
nTPM
GTEx:
23.0
nTPM
FANTOM5:
16.6
Scaled Tags Per Million
Pig:
0.1
nTPM
Mouse:
0.8
nTPM
HIPPOCAMPUS - Antibody stainingi
Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells.
Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.
Antibody HPA054148
Antibody HPA059929
Glial cells
Not detected
Not detected
Neuronal cells
Not detected
Not detected
HIPPOCAMPAL FORMATION - HPA Brain RNA-seq
Max nTPM
44.5
Sample id
Sample description
nTPM
Hippocampus nTPM: 36.0
1911
Female, age 85, right hemisphere
50.7
2621
Female, age 67, right hemisphere
39.5
2529
Female, age 94, left hemisphere
37.6
1855
Male, age 76, left hemisphere
33.6
2148
Female, age 91, left hemisphere
32.4
1898
Male, age 80, left hemisphere
21.9
Dentate gyrus nTPM: 38.7
2246
Female, age 85, both hemispheres
52.2
2530
Female, age 94, left hemisphere
45.3
2531
Female, age 67, both hemispheres
39.7
2010
Male, age 76, both hemispheres
34.3
2528
Male, age 74, both hemispheres
33.4
1927
Female, age 91, both hemispheres
27.4
Entorhinal gyrus nTPM: 41.1
2764
Male, age 80, right hemisphere
48.1
2686
Male, age 75, right hemisphere
46.0
2613
Female, age 94, left hemisphere
43.7
2117
Female, age 91, right hemisphere
43.5
1938
Female, age 85, left hemisphere
33.0
1787
Male, age 76, left hemisphere
32.6
Hippocampus, CA1 nTPM: 37.2
2082
Female, age 91, right hemisphere
50.0
2527
Male, age 74, both hemispheres
40.6
1873
Female, age 85, both hemispheres
38.4
2045
Male, age 76, both hemispheres
30.6
2749
Male, age 80, left hemisphere
26.5
Hippocampus, CA2 nTPM: 41.8
1940
Female, age 85, left hemisphere
62.9
2249
Male, age 74, both hemispheres
44.5
2437
Female, age 94, left hemisphere
39.8
2113
Female, age 91, right hemisphere
39.6
1963
Male, age 80, left hemisphere
37.4
1892
Male, age 76, both hemispheres
26.3
Hippocampus, CA3 nTPM: 30.4
1891
Female, age 85, both hemispheres
49.8
2861
Female, age 67, both hemispheres
29.8
2436
Male, age 74, both hemispheres
29.1
1867
Male, age 76, both hemispheres
25.8
2620
Female, age 94, left hemisphere
25.3
2137
Male, age 80, left hemisphere
22.3
Parahippocampal cortex nTPM: 37.0
2692
Male, age 74, both hemispheres
50.4
1990
Female, age 91, right hemisphere
43.3
2532
Female, age 72, left hemisphere
41.7
2693
Female, age 94, both hemispheres
40.5
2622
Female, age 67, right hemisphere
35.1
2245
Female, age 91, both hemispheres
34.6
2018
Male, age 76, both hemispheres
33.4
1850
Male, age 80, both hemispheres
30.9
2250
Female, age 67, right hemisphere
30.4
1933
Female, age 85, both hemispheres
29.6
Perirhinal gyrus nTPM: 25.8
2848
Male, age 76, right hemisphere
35.9
2521
Female, age 94, right hemisphere
25.9
1841
Female, age 85, right hemisphere
24.6
1794
Male, age 80, right hemisphere
22.2
1847
Female, age 91, left hemisphere
20.5
Subiculum nTPM: 44.5
2042
Male, age 76, both hemispheres
54.9
1901
Male, age 80, both hemispheres
53.8
2729
Female, age 91, right hemisphere
41.0
1977
Female, age 85, both hemispheres
39.1
2619
Male, age 74, both hemispheres
39.1
2438
Female, age 94, left hemisphere
38.9
HIPPOCAMPAL FORMATION - GTEx RNA-seqi
RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.
Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Average nTPM
23.0
GTEx sample id
Sample description
nTPM
Brain - Hippocampus Average nTPM: 23.0
Samples: 197
Max nTPM: 79.0
Min nTPM: 2.5
Std nTPM: 13.0
Median nTPM: 20.2
GTEX-18A6Q-0011-R1b-SM-731DI
60-69 years, male
79.0
GTEX-1LB8K-0011-R1b-SM-EZ6MV
50-59 years, male
67.0
GTEX-13RTJ-0011-R1a-SM-5O9D9
60-69 years, male
65.6
GTEX-1HBPI-0011-R1b-SM-A9SKF
50-59 years, male
62.8
GTEX-16GPK-0011-R1b-SM-7EWDH
60-69 years, male
57.4
GTEX-17HHY-0011-R1a-SM-7189V
50-59 years, male
55.3
GTEX-13N1W-0011-R1b-SM-5MR4T
70-79 years, male
53.0
GTEX-1H4P4-0011-R1b-SM-CL54V
50-59 years, male
48.1
GTEX-183WM-0011-R1a-SM-718A8
70-79 years, female
48.0
GTEX-1E2YA-0011-R1b-SM-CJI29
50-59 years, male
46.1
GTEX-13RTL-0011-R1a-SM-5PNZ8
40-49 years, male
45.3
GTEX-13OVL-0011-R1a-SM-5L3H5
50-59 years, male
44.5
GTEX-14LZ3-0011-R1a-SM-69LP5
60-69 years, female
43.5
GTEX-13OW5-0011-R1b-SM-5L3GE
60-69 years, male
43.4
GTEX-1H23P-0011-R1a-SM-ACKVC
60-69 years, male
43.4
GTEX-14PJM-0011-R1a-SM-CNPO3
50-59 years, female
43.1
GTEX-14PJO-0011-R1b-SM-6AJAK
60-69 years, male
42.8
GTEX-17HII-0011-R1b-SM-7MGVW
50-59 years, male
41.7
GTEX-1HR98-0011-R1a-SM-ARZLQ
60-69 years, male
41.0
GTEX-1EKGG-0011-R1b-SM-9QEI1
60-69 years, male
40.1
GTEX-UTHO-0011-R1A-SM-3GIJO
60-69 years, male
39.8
GTEX-13QIC-0011-R1a-SM-5O9CJ
60-69 years, female
39.4
GTEX-15UF6-0011-R1a-SM-9QEGH
70-79 years, female
38.7
GTEX-1I1GV-0011-R1a-SM-CL559
60-69 years, male
38.3
GTEX-1212Z-0011-R1b-SM-5BC72
60-69 years, male
38.1
GTEX-1I1GQ-0011-R1a-SM-CY8GG
50-59 years, male
37.8
GTEX-17EVP-0011-R1a-SM-7DHLA
40-49 years, male
37.3
GTEX-11GSO-0011-R1b-SM-57WD3
60-69 years, male
36.9
GTEX-1B933-0011-R1b-SM-9QEGW
50-59 years, female
36.7
GTEX-11ZVC-0011-R1b-SM-5BC6M
50-59 years, female
36.6
GTEX-14PQA-0011-R1b-SM-6EU1G
50-59 years, female
36.2
GTEX-1GN1U-0011-R1a-SM-CJI25
50-59 years, female
36.1
GTEX-1GN2E-0011-R1b-SM-CE6RJ
60-69 years, male
35.0
GTEX-17EVQ-0011-R1a-SM-7189S
70-79 years, male
34.5
GTEX-17MF6-0011-R1a-SM-72D6O
40-49 years, male
34.4
GTEX-1GN73-0011-R1a-SM-CKZNT
60-69 years, male
34.0
GTEX-13G51-0011-R1a-SM-5LZYR
60-69 years, male
33.8
GTEX-13JVG-0011-R1a-SM-5KM32
60-69 years, male
33.5
GTEX-1B8SF-0011-R1b-SM-7P8Q8
60-69 years, male
33.0
GTEX-13OW7-0011-R1b-SM-5L3HF
50-59 years, male
32.9
GTEX-1H1DG-0011-R1b-SM-CKZP1
70-79 years, male
32.9
GTEX-1H1CY-0011-R1a-SM-CKZOZ
60-69 years, female
31.6
GTEX-145LS-0011-R1b-SM-5PNUP
60-69 years, female
31.5
GTEX-ZAB4-0011-R1a-SM-4RGNO
40-49 years, male
31.4
GTEX-1H3NZ-0011-R1a-SM-CKZP5
60-69 years, male
31.4
GTEX-WZTO-0011-R1B-SM-3NMAR
40-49 years, male
31.1
GTEX-1F6IF-0011-R1b-SM-9WG78
60-69 years, male
30.7
GTEX-17JCI-0011-R1b-SM-718A3
60-69 years, female
30.5
GTEX-13NZA-0011-R1b-SM-5LUAF
60-69 years, male
30.1
GTEX-1H3O1-0011-R1b-SM-CL554
60-69 years, male
30.1
GTEX-12WSD-0011-R1b-SM-5LZVY
60-69 years, female
29.8
GTEX-1A32A-0011-R1a-SM-7P8SQ
50-59 years, female
29.6
GTEX-13N2G-0011-R1b-SM-5MR3G
60-69 years, male
29.3
GTEX-15ER7-0011-R1b-SM-7KUE1
20-29 years, female
29.3
GTEX-ZE7O-0011-R1a-SM-57WDM
50-59 years, female
29.3
GTEX-1EH9U-0011-R1b-SM-CJI2B
60-69 years, male
29.3
GTEX-1C6VQ-0011-R1a-SM-7P8Q2
50-59 years, male
28.7
GTEX-11UD1-0011-R1b-SM-5BC7D
40-49 years, female
28.6
GTEX-13QJC-0011-R1b-SM-5S2UU
60-69 years, female
28.4
GTEX-11ZTS-0011-R1a-SM-5BC71
60-69 years, female
27.6
GTEX-14E7W-0011-R1b-SM-5YYAT
70-79 years, male
27.3
GTEX-ZUA1-0011-R1a-SM-4YCE2
40-49 years, male
27.0
GTEX-13JUV-0011-R1a-SM-5LZY4
40-49 years, female
26.5
GTEX-13S7M-0011-R1b-SM-5PNZE
60-69 years, female
25.9
GTEX-12WSM-0011-R1a-SM-5LZW6
60-69 years, male
25.6
GTEX-17HG3-0011-R1a-SM-7LG6H
30-39 years, female
25.4
GTEX-11WQC-0011-R1b-SM-DO932
60-69 years, male
25.3
GTEX-15CHQ-0011-R1a-SM-COH27
60-69 years, male
24.9
GTEX-1F6I4-0011-R1a-SM-9OSWU
60-69 years, male
24.9
GTEX-QMR6-0011-R1A-SM-32PKW
50-59 years, male
24.7
GTEX-16Z82-0011-R1b-SM-7EPHZ
60-69 years, male
24.3
GTEX-X4XX-0011-R1B-SM-3P622
60-69 years, male
24.3
GTEX-13OW6-0011-R1a-SM-5L3HQ
50-59 years, male
24.1
GTEX-1BAJH-0011-R1a-SM-7P8SV
70-79 years, male
23.9
GTEX-1C6VR-0011-R1a-SM-7MXUE
60-69 years, male
23.8
GTEX-1IDJH-0011-R1b-SM-ARU6U
70-79 years, male
23.6
GTEX-1GTWX-0011-R1a-SM-CE6RL
60-69 years, male
23.5
GTEX-1H1ZS-0011-R1b-SM-A9G1E
70-79 years, male
23.5
GTEX-12WSF-0011-R1a-SM-5DUVI
70-79 years, male
23.4
GTEX-ZVZQ-0011-R1a-SM-57WBU
60-69 years, female
23.4
GTEX-1E1VI-0011-R1a-SM-ARZMM
50-59 years, male
23.2
GTEX-Y8DK-0011-R1A-SM-4RGLO
60-69 years, male
23.1
GTEX-1CB4G-0011-R1b-SM-9QEHT
60-69 years, male
22.2
GTEX-1F48J-0011-R1a-SM-9QEIC
50-59 years, female
21.9
GTEX-11DXW-0011-R1a-SM-DNZZD
40-49 years, male
21.7
GTEX-N7MT-0011-R1a-SM-CNPO1
60-69 years, female
21.7
GTEX-1I1HK-0011-R1b-SM-CM2T7
60-69 years, male
21.4
GTEX-1EX96-0011-R1a-SM-CE6R5
50-59 years, male
21.3
GTEX-14E6D-0011-R1b-SM-5YYAW
50-59 years, male
21.2
GTEX-P44H-0011-R1A-SM-3NM8J
40-49 years, male
21.1
GTEX-13OW8-0011-R1a-SM-5L3HI
60-69 years, male
20.8
GTEX-X585-0011-R1B-SM-46MVE
50-59 years, male
20.8
GTEX-WVLH-0011-R1A-SM-4MVOK
50-59 years, male
20.7
GTEX-1C64N-0011-R1b-SM-7P8Q7
50-59 years, male
20.7
GTEX-QVJO-0011-R1A-SM-2S1QI
60-69 years, female
20.4
GTEX-139TT-0011-R1a-SM-5LZVD
60-69 years, male
20.3
GTEX-1I1GS-0011-R1a-SM-CJI43
60-69 years, male
20.3
GTEX-16XZZ-0011-R1a-SM-7LTAH
60-69 years, male
20.2
GTEX-1HSKV-0011-R1b-SM-CMKH7
60-69 years, male
20.2
GTEX-S7SE-0011-R1A-SM-2XCDE
50-59 years, male
19.8
GTEX-1IOXB-0011-R1a-SM-D4P27
50-59 years, male
19.8
GTEX-16NPV-0011-R1b-SM-7MGVZ
50-59 years, female
19.6
GTEX-OHPN-0011-R1A-SM-2I5GB
60-69 years, female
19.5
GTEX-QVUS-0011-R1A-SM-3GAD2
60-69 years, female
19.4
GTEX-1B996-0011-R1b-SM-7P8PO
60-69 years, male
19.4
GTEX-1GZ2Q-0011-R1a-SM-CJI2Y
40-49 years, male
19.4
GTEX-11EI6-0011-R1a-SM-DO93L
60-69 years, male
19.2
GTEX-XMD1-0011-R1A-SM-4AT4C
60-69 years, male
18.9
GTEX-13FHP-0011-R1b-SM-5K7XL
50-59 years, male
18.6
GTEX-11GSP-0011-R1a-SM-9QEJ3
60-69 years, female
18.5
GTEX-13FTY-0011-R1a-SM-5LZXE
40-49 years, female
18.4
GTEX-WL46-0011-R1A-SM-3LK6M
50-59 years, male
18.3
GTEX-13FXS-0011-R1a-SM-5K7U6
50-59 years, male
18.1
GTEX-13CF2-0011-R1a-SM-5LZY1
60-69 years, male
17.8
GTEX-15DCD-0011-R1b-SM-6LPIJ
70-79 years, female
17.8
GTEX-11ONC-0011-R1a-SM-57WD4
60-69 years, male
17.7
GTEX-13X6I-0011-R1b-SM-5PNZC
60-69 years, male
17.7
GTEX-1A8G6-0011-R1a-SM-7P8PC
60-69 years, male
17.6
GTEX-13112-0011-R1b-SM-5HL7K
50-59 years, male
17.4
GTEX-1399T-0011-R1b-SM-5DUWN
60-69 years, male
17.3
GTEX-1313W-0011-R1b-SM-5EQ4A
50-59 years, female
17.1
GTEX-1H3VE-0011-R1a-SM-A9G1K
40-49 years, male
16.9
GTEX-17F97-0011-R1b-SM-7IGM9
50-59 years, male
16.5
GTEX-Q2AG-0011-R1A-SM-2HMJI
40-49 years, female
16.5
GTEX-YFC4-0011-R1a-SM-4V6EH
40-49 years, female
16.5
GTEX-12WSE-0011-R1b-SM-5GU4V
20-29 years, male
16.4
GTEX-1HGF4-0011-R1a-SM-CJI3S
60-69 years, male
16.4
GTEX-1AX9I-0011-R1b-SM-7RHG2
60-69 years, male
16.1
GTEX-1IKK5-0011-R1b-SM-CE6SQ
60-69 years, male
15.5
GTEX-13NYB-0011-R1b-SM-5KM4F
40-49 years, male
15.3
GTEX-144GO-0011-R1a-SM-5PNWO
60-69 years, male
15.3
GTEX-N7MS-0011-R1a-SM-2HMJG
60-69 years, male
15.3
GTEX-NPJ7-0011-R1a-SM-3GACT
60-69 years, female
15.2
GTEX-1B8L1-0011-R1a-SM-7P8SS
60-69 years, male
15.2
GTEX-T5JC-0011-R1A-SM-32PM6
20-29 years, male
15.1
GTEX-11GS4-0011-R1a-SM-DO129
60-69 years, male
15.0
GTEX-1GF9V-0011-R1a-SM-CKZNQ
60-69 years, male
14.8
GTEX-1J1OQ-0011-R1a-SM-A9G1Z
40-49 years, female
14.8
GTEX-13NYS-0011-R1b-SM-5MR55
60-69 years, male
14.6
GTEX-14C5O-0011-R1b-SM-6AJBW
60-69 years, male
14.6
GTEX-131XH-0011-R1a-SM-5DUWA
50-59 years, male
14.5
GTEX-13O3O-0011-R1b-SM-5KM2K
60-69 years, female
14.3
GTEX-145LU-0011-R1a-SM-5Q5CE
50-59 years, male
14.2
GTEX-12ZZX-0011-R1a-SM-5EQ6B
40-49 years, female
13.8
GTEX-13OVJ-0011-R1b-SM-5L3I6
50-59 years, female
13.7
GTEX-13SLW-0011-R1a-SM-5S2W7
70-79 years, male
13.6
GTEX-14ASI-0011-R1b-SM-5S2TY
60-69 years, male
13.6
GTEX-1F75A-0011-R1b-SM-CE6RA
50-59 years, male
13.6
GTEX-PVOW-0011-R1A-SM-32PL6
40-49 years, male
13.3
GTEX-T6MN-0011-R1A-SM-32QOY
50-59 years, male
13.1
GTEX-13O3Q-0011-R1b-SM-5KM3L
50-59 years, male
13.0
GTEX-12WSH-0011-R1a-SM-5GU5V
50-59 years, male
12.9
GTEX-WWYW-0011-R1A-SM-3TW8G
50-59 years, female
12.7
GTEX-14ABY-0011-R1a-SM-6EU2W
50-59 years, male
12.5
GTEX-14PN4-0011-R1b-SM-69LP8
50-59 years, male
12.4
GTEX-YJ89-0011-R1a-SM-4RGLS
60-69 years, male
12.4
GTEX-1GZHY-0011-R1a-SM-CE6RR
50-59 years, female
12.3
GTEX-1EWIQ-0011-R1a-SM-9OSX7
70-79 years, female
12.1
GTEX-14BIM-0011-R1a-SM-69LQI
60-69 years, female
12.0
GTEX-13FHO-0011-R1b-SM-5KLZG
60-69 years, male
11.8
GTEX-1HSMO-0011-R1a-SM-CM2SV
60-69 years, male
11.8
GTEX-RNOR-0011-R1A-SM-CNNP5
50-59 years, female
11.7
GTEX-13PDP-0011-R1a-SM-5PNX5
60-69 years, male
11.6
GTEX-1J8Q2-0011-R1a-SM-D4P2D
60-69 years, male
11.4
GTEX-1A3MX-0011-R1b-SM-7P8PH
60-69 years, male
11.2
GTEX-11TUW-0011-R1a-SM-DO92S
60-69 years, male
10.9
GTEX-14JIY-0011-R1a-SM-68713
60-69 years, male
10.8
GTEX-1F75W-0011-R1a-SM-ARU81
60-69 years, male
10.8
GTEX-1GF9W-0011-R1a-SM-9QEIQ
60-69 years, male
10.7
GTEX-ZDXO-0011-R1a-SM-4WKF4
60-69 years, male
10.4
GTEX-132Q8-0011-R1a-SM-5EGLK
60-69 years, male
10.3
GTEX-PWO3-0011-R1A-SM-2I5EW
60-69 years, female
10.2
GTEX-WHSE-0011-R1A-SM-3P5ZK
20-29 years, male
10.2
GTEX-16YQH-0011-R1a-SM-7LT8R
30-39 years, male
10.1
GTEX-13FLW-0011-R1b-SM-5LZX2
50-59 years, male
10.0
GTEX-NPJ8-0011-R1a-SM-33HCB
40-49 years, male
10.0
GTEX-1IY9M-0011-R1a-SM-EXURZ
60-69 years, male
9.9
GTEX-NL3H-0011-R1a-SM-48TDJ
60-69 years, male
9.1
GTEX-1GMR8-0011-R1b-SM-CJI2O
50-59 years, female
9.1
GTEX-13NZ8-0011-R1b-SM-5KM3V
60-69 years, female
8.9
GTEX-ZF28-0011-R1a-SM-4WWD1
60-69 years, male
8.8
GTEX-14LLW-0011-R1a-SM-5ZZVD
70-79 years, female
8.7
GTEX-R55E-0011-R1A-SM-2TC6N
20-29 years, male
8.6
GTEX-1EMGI-0011-R1b-SM-9OSWZ
60-69 years, male
8.3
GTEX-144GL-0011-R1a-SM-5PNZ5
50-59 years, male
8.1
GTEX-1CAV2-0011-R1a-SM-ARZML
40-49 years, female
7.4
GTEX-1ICLZ-0011-R1b-SM-A9SM3
60-69 years, male
7.2
GTEX-131YS-0011-R1a-SM-5DUXC
60-69 years, female
6.9
GTEX-145MH-0011-R1b-SM-5PNWY
50-59 years, male
6.8
GTEX-QDT8-0011-R1A-SM-32PKS
30-39 years, female
6.6
GTEX-TSE9-0011-R1A-SM-3DB7E
60-69 years, female
6.5
GTEX-1LG7Y-0011-R1a-SM-EYYWV
50-59 years, male
6.4
GTEX-P44G-0011-R1A-SM-2I3FE
30-39 years, male
6.3
GTEX-1HT8W-0011-R1b-SM-CJI3V
30-39 years, male
6.3
GTEX-1CB4J-0011-R1a-SM-9WG64
60-69 years, male
4.7
GTEX-139T8-0011-R1a-SM-5HL75
60-69 years, male
4.0
GTEX-X4EP-0011-R1A-SM-3P624
60-69 years, female
2.5
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HIPPOCAMPAL FORMATION - FANTOM5 CAGEi
RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.
Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.