Subcellular - LTV1 - The Human Protein Atlas

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LTV1

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Field

Cluster

Pathway

SUMMARY

TISSUE

BRAIN

SINGLE CELL

TISSUE CELL

PATHOLOGY

DISEASE

IMMUNE

BLOOD

SUBCELL

CELL LINE

STRUCTURE

INTERACTION

LTV1

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	LTV1
Gene descriptionⁱ Full gene name according to HGNC.	LTV1 ribosome biogenesis factor
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Main locationⁱ Main subcellular location(s) and reliability score(s) for the encoded protein(s) in human cells. The main location(s) may be characterized by presence in all tested cell lines and/or ihigher staining intensity compared to the potential additional location(s). If available, links to overrepresentation analyses in Reactome, a free, open-source, curated and peer reviewed biological pathway database, are provided. An analysis is done for the corresponding gene set of the proteome localizing to the main and additional locations of the protein on this page, respectively.	Localized to the Cytosol (enhanced)
Additional locationⁱ Additonal subcellular location(s) for the encoded protein(s) in human cells. The additional location(s) may not be present i all cell lines and may have lower staining intensity compared to the main location(s). If available, links to overrepresentation analyses in Reactome, a free, open-source, curated and peer reviewed biological pathway database, are provided. An analysis is done for the corresponding gene set of the proteome localizing to the main and additional locations of the protein on this page, respectively.	In addition localized to the Nucleoplasm (enhanced)
siRNAⁱ Validation score for the subcellular location(s) of the encoded proteins(s) according to siRNA validation.	The location(s) are Enhanced based on siRNA mediated gene silencing.
Reliability scoreⁱ Overall gene reliability score for the subcellular location(s) of the encoded protein(s). The score indicates the level of reliability of the annotated protein localization based on agreement with available experimental gene/protein characterization data in the UniProtKB/Swiss-Prot database and presence of antibody validation assays for immunocytochemistry.	Enhanced
Antibodiesⁱ Antibodies used for this assay. Click on an antibody for more information.	HPA030159 , HPA030160
	SHOW MORE

ASSAYSⁱ

RNA expression

Human cells

siRNA

RNA EXPRESSION OVERVIEWⁱ

Organ

Origin

Category

Expression

Alphabetical

Cell lines ordered by organ of phenotypic resemblance.

HUMAN CELLSⁱ

Summaryⁱ

Mainly localized to the cytosol. In addition localized to the nucleoplasm.

Main locationⁱ

Cytosol (enhanced)

Additional locationⁱ

Nucleoplasm (enhanced)


	Toggle channelsⁱ Buttons for turning on and off the different channels in the multi-color images. The intensity toggle shows the pixel intensity range in 16 different colors for the selected channel. The object toggle shows the computational segmentation of the cells used for further analysis in the HPA project. For samples where cell cycle dependency for the protein is suggested according to a correlation assay the predicted cell cycle position of each cell is displayed when using the object toggle.	Low High

Antibodyⁱ Antibody used for analysis. Clicking the antibody ID links to the antibody validation page.	Cell lineⁱ Cell line used for analysis. Read more about the cell lines in the Human Protein Atlas.	Cell line RNA Expression (nTPM)ⁱ RNA expression level in the cell line based on normalised RNA sequencing data. Genes with a value above 1 NX are considered to be expressed.	Locationⁱ Observed subcellular location(s).
HPA030159	A-431	48.8	Nucleoplasm
HPA030159	A-431	48.8	Cytosol
HPA030159	U-251MG	79.3	Nucleoplasm
HPA030159	U-251MG	79.3	Cytosol
HPA030159	U2OS	43.8	Nucleoplasm
HPA030159	U2OS	43.8	Cytosol
HPA030160	A-431	48.8	Nucleoplasm
HPA030160	A-431	48.8	Cytosol
HPA030160	U-251MG	79.3	Nucleoplasm
HPA030160	U-251MG	79.3	Cytosol
HPA030160	U2OS	43.8	Nucleoplasm
HPA030160	U2OS	43.8	Cytosol

siRNA VALIDATIONⁱ

Antibodyⁱ

HPA030159

siRNA validationⁱ

Enhanced: Significant downregulation > 25% by one siRNA.

Analysis performed inⁱ

Cytoplasmic region of segmented cells in 10x-images

siRNA 1ⁱ

RFIⁱ

39%

p-valueⁱ

< 0.01


	Toggle channelsⁱ Buttons for turning on and off the different channels in the multi-color images. The intensity toggle shows the pixel intensity range in 16 different colors for the selected channel. The antibody and intensity channel toggle can be used to further illustrate the intensity downregulation when comparing images from scrambled and targeting siRNA samples in the images. The object toggle shows the segmentation compartment in which the change in intensity after siRNA downregulation was measured.	Low High

Thumbnail 10xⁱ Minatures of all available images acquired with a 10x objective after siRNA downregulation. The checkboxes can be used to select which three images to compare in the window above. All images are also clickable for an enlarged view. The selected image will appear in large size and miniature images with all other staining results for this gene will be listed at the top left of the image.	Thumbnail 40xⁱ Minatures of all available images acquired with a 40x objective after siRNA downregulation. The checkboxes can be used to select which three images to compare in the window above. All images are also clickable for an enlarged view. The selected image will appear in large size and miniature images with all other staining results for this gene will be listed at the top left of the image.	Antibodyⁱ Antibody used for analysis. Clicking the antibody ID links to the antibody validation page.	Sampleⁱ siRNA that was used for the analysis.	Cell lineⁱ Cell line used for analysis. Read more about the cell lines in the Human Protein Atlas.
		HPA030159	siRNA 1	U2OS
		HPA030159	scrambled	U2OS

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.

contact@proteinatlas.org