GENERAL INFORMATIONi
Gene namei SNCA
Synonyms NACP, PARK1, PARK4, PD1
Gene descriptioni Synuclein alpha
Protein classi Disease related genes
Human disease related genes
Plasma proteins
Potential drug targets
Transporters
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 4
Cytoband q22.1
Chromosome location (bp) 89700345 - 89838315
Number of transcriptsi 16
Ensembl ENSG00000145335 (version 109)
Entrez gene 6622
HGNC HGNC:11138
UniProt P37840 (UniProt - Evidence at protein level)
neXtProt NX_P37840
GeneCards SNCA
Antibodypedia SNCA antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release 1, 2, 3, 4. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores 5, 6. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis 7. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 8. This chaperone activity is important to sustain normal SNARE-complex assembly during aging 9. Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity 10. show less
Ligand (UniProt)i Copper, Metal-binding
Gene summary (Entrez)i Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
SNCA-201
ENSP00000338345
ENST00000336904
P37840
[Direct mapping] Alpha-synuclein
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Disease related genes
Potential drug targets
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000149 [SNARE binding]
GO:0000287 [magnesium ion binding]
GO:0000976 [transcription cis-regulatory region binding]
GO:0001774 [microglial cell activation]
GO:0001921 [positive regulation of receptor recycling]
GO:0003779 [actin binding]
GO:0004860 [protein kinase inhibitor activity]
GO:0005507 [copper ion binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005764 [lysosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007268 [chemical synaptic transmission]
GO:0008198 [ferrous iron binding]
GO:0008270 [zinc ion binding]
GO:0008289 [lipid binding]
GO:0010040 [response to iron(II) ion]
GO:0010517 [regulation of phospholipase activity]
GO:0010642 [negative regulation of platelet-derived growth factor receptor signaling pathway]
GO:0014059 [regulation of dopamine secretion]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0016082 [synaptic vesicle priming]
GO:0016234 [inclusion body]
GO:0016491 [oxidoreductase activity]
GO:0019894 [kinesin binding]
GO:0022898 [regulation of transmembrane transporter activity]
GO:0030424 [axon]
GO:0030426 [growth cone]
GO:0030544 [Hsp70 protein binding]
GO:0031092 [platelet alpha granule membrane]
GO:0031115 [negative regulation of microtubule polymerization]
GO:0031623 [receptor internalization]
GO:0031648 [protein destabilization]
GO:0032026 [response to magnesium ion]
GO:0032410 [negative regulation of transporter activity]
GO:0032496 [response to lipopolysaccharide]
GO:0032769 [negative regulation of monooxygenase activity]
GO:0032991 [protein-containing complex]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034341 [response to type II interferon]
GO:0034599 [cellular response to oxidative stress]
GO:0035067 [negative regulation of histone acetylation]
GO:0035493 [SNARE complex assembly]
GO:0035543 [positive regulation of SNARE complex assembly]
GO:0042393 [histone binding]
GO:0042416 [dopamine biosynthetic process]
GO:0042802 [identical protein binding]
GO:0042995 [cell projection]
GO:0043014 [alpha-tubulin binding]
GO:0043025 [neuronal cell body]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043679 [axon terminus]
GO:0045202 [synapse]
GO:0045807 [positive regulation of endocytosis]
GO:0045920 [negative regulation of exocytosis]
GO:0045921 [positive regulation of exocytosis]
GO:0046872 [metal ion binding]
GO:0048156 [tau protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048488 [synaptic vesicle endocytosis]
GO:0050729 [positive regulation of inflammatory response]
GO:0050808 [synapse organization]
GO:0051179 [localization]
GO:0051219 [phosphoprotein binding]
GO:0051262 [protein tetramerization]
GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol]
GO:0051583 [dopamine uptake involved in synaptic transmission]
GO:0051585 [negative regulation of dopamine uptake involved in synaptic transmission]
GO:0051612 [negative regulation of serotonin uptake]
GO:0051621 [regulation of norepinephrine uptake]
GO:0051622 [negative regulation of norepinephrine uptake]
GO:0060090 [molecular adaptor activity]
GO:0060732 [positive regulation of inositol phosphate biosynthetic process]
GO:0070495 [negative regulation of thrombin-activated receptor signaling pathway]
GO:0070555 [response to interleukin-1]
GO:0070840 [dynein complex binding]
GO:0071280 [cellular response to copper ion]
GO:0071872 [cellular response to epinephrine stimulus]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0097435 [supramolecular fiber organization]
GO:0098794 [postsynapse]
GO:0099512 [supramolecular fiber]
GO:1901214 [regulation of neuron death]
GO:1901215 [negative regulation of neuron death]
GO:1901216 [positive regulation of neuron death]
GO:1902957 [negative regulation of mitochondrial electron transport, NADH to ubiquinone]
GO:1903136 [cuprous ion binding]
GO:1903284 [positive regulation of glutathione peroxidase activity]
GO:1903285 [positive regulation of hydrogen peroxide catabolic process]
GO:1903421 [regulation of synaptic vesicle recycling]
GO:1903426 [regulation of reactive oxygen species biosynthetic process]
GO:1904715 [negative regulation of chaperone-mediated autophagy]
GO:1905606 [regulation of presynapse assembly]
GO:1990000 [amyloid fibril formation]
Show all
 140 aa
14.5 kDa 		No 0
SNCA-202
ENSP00000343683
ENST00000345009
P37840
[Direct mapping] Alpha-synuclein
Show all
H6UYS5
[Target identity:100%; Query identity:100%] Alpha-synuclein
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Disease related genes
Potential drug targets
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000149 [SNARE binding]
GO:0000287 [magnesium ion binding]
GO:0000976 [transcription cis-regulatory region binding]
GO:0001774 [microglial cell activation]
GO:0001921 [positive regulation of receptor recycling]
GO:0003779 [actin binding]
GO:0004860 [protein kinase inhibitor activity]
GO:0005507 [copper ion binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005764 [lysosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007268 [chemical synaptic transmission]
GO:0008198 [ferrous iron binding]
GO:0008270 [zinc ion binding]
GO:0008289 [lipid binding]
GO:0010040 [response to iron(II) ion]
GO:0010517 [regulation of phospholipase activity]
GO:0010642 [negative regulation of platelet-derived growth factor receptor signaling pathway]
GO:0014059 [regulation of dopamine secretion]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0016082 [synaptic vesicle priming]
GO:0016234 [inclusion body]
GO:0016491 [oxidoreductase activity]
GO:0019894 [kinesin binding]
GO:0022898 [regulation of transmembrane transporter activity]
GO:0030424 [axon]
GO:0030426 [growth cone]
GO:0030544 [Hsp70 protein binding]
GO:0031092 [platelet alpha granule membrane]
GO:0031115 [negative regulation of microtubule polymerization]
GO:0031623 [receptor internalization]
GO:0031648 [protein destabilization]
GO:0032026 [response to magnesium ion]
GO:0032410 [negative regulation of transporter activity]
GO:0032496 [response to lipopolysaccharide]
GO:0032769 [negative regulation of monooxygenase activity]
GO:0032991 [protein-containing complex]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034341 [response to type II interferon]
GO:0034599 [cellular response to oxidative stress]
GO:0035067 [negative regulation of histone acetylation]
GO:0035493 [SNARE complex assembly]
GO:0035543 [positive regulation of SNARE complex assembly]
GO:0042393 [histone binding]
GO:0042416 [dopamine biosynthetic process]
GO:0042802 [identical protein binding]
GO:0042995 [cell projection]
GO:0043014 [alpha-tubulin binding]
GO:0043025 [neuronal cell body]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043679 [axon terminus]
GO:0045202 [synapse]
GO:0045807 [positive regulation of endocytosis]
GO:0045920 [negative regulation of exocytosis]
GO:0045921 [positive regulation of exocytosis]
GO:0046872 [metal ion binding]
GO:0048156 [tau protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048488 [synaptic vesicle endocytosis]
GO:0050729 [positive regulation of inflammatory response]
GO:0050808 [synapse organization]
GO:0051179 [localization]
GO:0051219 [phosphoprotein binding]
GO:0051262 [protein tetramerization]
GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol]
GO:0051583 [dopamine uptake involved in synaptic transmission]
GO:0051585 [negative regulation of dopamine uptake involved in synaptic transmission]
GO:0051612 [negative regulation of serotonin uptake]
GO:0051621 [regulation of norepinephrine uptake]
GO:0051622 [negative regulation of norepinephrine uptake]
GO:0060090 [molecular adaptor activity]
GO:0060732 [positive regulation of inositol phosphate biosynthetic process]
GO:0070495 [negative regulation of thrombin-activated receptor signaling pathway]
GO:0070555 [response to interleukin-1]
GO:0070840 [dynein complex binding]
GO:0071280 [cellular response to copper ion]
GO:0071872 [cellular response to epinephrine stimulus]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0097435 [supramolecular fiber organization]
GO:0098794 [postsynapse]
GO:0099512 [supramolecular fiber]
GO:1901214 [regulation of neuron death]
GO:1901215 [negative regulation of neuron death]
GO:1901216 [positive regulation of neuron death]
GO:1902957 [negative regulation of mitochondrial electron transport, NADH to ubiquinone]
GO:1903136 [cuprous ion binding]
GO:1903284 [positive regulation of glutathione peroxidase activity]
GO:1903285 [positive regulation of hydrogen peroxide catabolic process]
GO:1903421 [regulation of synaptic vesicle recycling]
GO:1903426 [regulation of reactive oxygen species biosynthetic process]
GO:1904715 [negative regulation of chaperone-mediated autophagy]
GO:1905606 [regulation of presynapse assembly]
GO:1990000 [amyloid fibril formation]
Show all
 112 aa
11.4 kDa 		No 0
SNCA-203
ENSP00000378437
ENST00000394986
P37840
[Direct mapping] Alpha-synuclein
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Disease related genes
Potential drug targets
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000149 [SNARE binding]
GO:0000287 [magnesium ion binding]
GO:0000976 [transcription cis-regulatory region binding]
GO:0001774 [microglial cell activation]
GO:0001921 [positive regulation of receptor recycling]
GO:0003779 [actin binding]
GO:0004860 [protein kinase inhibitor activity]
GO:0005507 [copper ion binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005764 [lysosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007268 [chemical synaptic transmission]
GO:0008198 [ferrous iron binding]
GO:0008270 [zinc ion binding]
GO:0008289 [lipid binding]
GO:0010040 [response to iron(II) ion]
GO:0010517 [regulation of phospholipase activity]
GO:0010642 [negative regulation of platelet-derived growth factor receptor signaling pathway]
GO:0014059 [regulation of dopamine secretion]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0016082 [synaptic vesicle priming]
GO:0016234 [inclusion body]
GO:0016491 [oxidoreductase activity]
GO:0019894 [kinesin binding]
GO:0022898 [regulation of transmembrane transporter activity]
GO:0030424 [axon]
GO:0030426 [growth cone]
GO:0030544 [Hsp70 protein binding]
GO:0031092 [platelet alpha granule membrane]
GO:0031115 [negative regulation of microtubule polymerization]
GO:0031623 [receptor internalization]
GO:0031648 [protein destabilization]
GO:0032026 [response to magnesium ion]
GO:0032410 [negative regulation of transporter activity]
GO:0032496 [response to lipopolysaccharide]
GO:0032769 [negative regulation of monooxygenase activity]
GO:0032991 [protein-containing complex]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034341 [response to type II interferon]
GO:0034599 [cellular response to oxidative stress]
GO:0035067 [negative regulation of histone acetylation]
GO:0035493 [SNARE complex assembly]
GO:0035543 [positive regulation of SNARE complex assembly]
GO:0042393 [histone binding]
GO:0042416 [dopamine biosynthetic process]
GO:0042802 [identical protein binding]
GO:0042995 [cell projection]
GO:0043014 [alpha-tubulin binding]
GO:0043025 [neuronal cell body]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043679 [axon terminus]
GO:0045202 [synapse]
GO:0045807 [positive regulation of endocytosis]
GO:0045920 [negative regulation of exocytosis]
GO:0045921 [positive regulation of exocytosis]
GO:0046872 [metal ion binding]
GO:0048156 [tau protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048488 [synaptic vesicle endocytosis]
GO:0050729 [positive regulation of inflammatory response]
GO:0050808 [synapse organization]
GO:0051179 [localization]
GO:0051219 [phosphoprotein binding]
GO:0051262 [protein tetramerization]
GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol]
GO:0051583 [dopamine uptake involved in synaptic transmission]
GO:0051585 [negative regulation of dopamine uptake involved in synaptic transmission]
GO:0051612 [negative regulation of serotonin uptake]
GO:0051621 [regulation of norepinephrine uptake]
GO:0051622 [negative regulation of norepinephrine uptake]
GO:0060090 [molecular adaptor activity]
GO:0060732 [positive regulation of inositol phosphate biosynthetic process]
GO:0070495 [negative regulation of thrombin-activated receptor signaling pathway]
GO:0070555 [response to interleukin-1]
GO:0070840 [dynein complex binding]
GO:0071280 [cellular response to copper ion]
GO:0071872 [cellular response to epinephrine stimulus]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0097435 [supramolecular fiber organization]
GO:0098794 [postsynapse]
GO:0099512 [supramolecular fiber]
GO:1901214 [regulation of neuron death]
GO:1901215 [negative regulation of neuron death]
GO:1901216 [positive regulation of neuron death]
GO:1902957 [negative regulation of mitochondrial electron transport, NADH to ubiquinone]
GO:1903136 [cuprous ion binding]
GO:1903284 [positive regulation of glutathione peroxidase activity]
GO:1903285 [positive regulation of hydrogen peroxide catabolic process]
GO:1903421 [regulation of synaptic vesicle recycling]
GO:1903426 [regulation of reactive oxygen species biosynthetic process]
GO:1904715 [negative regulation of chaperone-mediated autophagy]
GO:1905606 [regulation of presynapse assembly]
GO:1990000 [amyloid fibril formation]
Show all
 140 aa
14.5 kDa 		No 0
SNCA-204
ENSP00000378440
ENST00000394989
P37840
[Direct mapping] Alpha-synuclein
Show all
H6UYS0
[Target identity:100%; Query identity:100%] Alpha-synuclein
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Disease related genes
Potential drug targets
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000149 [SNARE binding]
GO:0000287 [magnesium ion binding]
GO:0000976 [transcription cis-regulatory region binding]
GO:0001774 [microglial cell activation]
GO:0001921 [positive regulation of receptor recycling]
GO:0003779 [actin binding]
GO:0004860 [protein kinase inhibitor activity]
GO:0005507 [copper ion binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005764 [lysosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007268 [chemical synaptic transmission]
GO:0008198 [ferrous iron binding]
GO:0008270 [zinc ion binding]
GO:0008289 [lipid binding]
GO:0010040 [response to iron(II) ion]
GO:0010517 [regulation of phospholipase activity]
GO:0010642 [negative regulation of platelet-derived growth factor receptor signaling pathway]
GO:0014059 [regulation of dopamine secretion]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0016082 [synaptic vesicle priming]
GO:0016234 [inclusion body]
GO:0016491 [oxidoreductase activity]
GO:0019894 [kinesin binding]
GO:0022898 [regulation of transmembrane transporter activity]
GO:0030424 [axon]
GO:0030426 [growth cone]
GO:0030544 [Hsp70 protein binding]
GO:0031092 [platelet alpha granule membrane]
GO:0031115 [negative regulation of microtubule polymerization]
GO:0031623 [receptor internalization]
GO:0031648 [protein destabilization]
GO:0032026 [response to magnesium ion]
GO:0032410 [negative regulation of transporter activity]
GO:0032496 [response to lipopolysaccharide]
GO:0032769 [negative regulation of monooxygenase activity]
GO:0032991 [protein-containing complex]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034341 [response to type II interferon]
GO:0034599 [cellular response to oxidative stress]
GO:0035067 [negative regulation of histone acetylation]
GO:0035493 [SNARE complex assembly]
GO:0035543 [positive regulation of SNARE complex assembly]
GO:0042393 [histone binding]
GO:0042416 [dopamine biosynthetic process]
GO:0042802 [identical protein binding]
GO:0042995 [cell projection]
GO:0043014 [alpha-tubulin binding]
GO:0043025 [neuronal cell body]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043679 [axon terminus]
GO:0045202 [synapse]
GO:0045807 [positive regulation of endocytosis]
GO:0045920 [negative regulation of exocytosis]
GO:0045921 [positive regulation of exocytosis]
GO:0046872 [metal ion binding]
GO:0048156 [tau protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048488 [synaptic vesicle endocytosis]
GO:0050729 [positive regulation of inflammatory response]
GO:0050808 [synapse organization]
GO:0051179 [localization]
GO:0051219 [phosphoprotein binding]
GO:0051262 [protein tetramerization]
GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol]
GO:0051583 [dopamine uptake involved in synaptic transmission]
GO:0051585 [negative regulation of dopamine uptake involved in synaptic transmission]
GO:0051612 [negative regulation of serotonin uptake]
GO:0051621 [regulation of norepinephrine uptake]
GO:0051622 [negative regulation of norepinephrine uptake]
GO:0060090 [molecular adaptor activity]
GO:0060732 [positive regulation of inositol phosphate biosynthetic process]
GO:0070495 [negative regulation of thrombin-activated receptor signaling pathway]
GO:0070555 [response to interleukin-1]
GO:0070840 [dynein complex binding]
GO:0071280 [cellular response to copper ion]
GO:0071872 [cellular response to epinephrine stimulus]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0097435 [supramolecular fiber organization]
GO:0098794 [postsynapse]
GO:0099512 [supramolecular fiber]
GO:1901214 [regulation of neuron death]
GO:1901215 [negative regulation of neuron death]
GO:1901216 [positive regulation of neuron death]
GO:1902957 [negative regulation of mitochondrial electron transport, NADH to ubiquinone]
GO:1903136 [cuprous ion binding]
GO:1903284 [positive regulation of glutathione peroxidase activity]
GO:1903285 [positive regulation of hydrogen peroxide catabolic process]
GO:1903421 [regulation of synaptic vesicle recycling]
GO:1903426 [regulation of reactive oxygen species biosynthetic process]
GO:1904715 [negative regulation of chaperone-mediated autophagy]
GO:1905606 [regulation of presynapse assembly]
GO:1990000 [amyloid fibril formation]
Show all
 126 aa
13.1 kDa 		No 0
SNCA-205
ENSP00000378442
ENST00000394991
P37840
[Direct mapping] Alpha-synuclein
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Disease related genes
Potential drug targets
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000149 [SNARE binding]
GO:0000287 [magnesium ion binding]
GO:0000976 [transcription cis-regulatory region binding]
GO:0001774 [microglial cell activation]
GO:0001921 [positive regulation of receptor recycling]
GO:0001956 [positive regulation of neurotransmitter secretion]
GO:0001963 [synaptic transmission, dopaminergic]
GO:0003779 [actin binding]
GO:0004860 [protein kinase inhibitor activity]
GO:0005507 [copper ion binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005764 [lysosome]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006631 [fatty acid metabolic process]
GO:0006638 [neutral lipid metabolic process]
GO:0006644 [phospholipid metabolic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007006 [mitochondrial membrane organization]
GO:0007268 [chemical synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0008198 [ferrous iron binding]
GO:0008270 [zinc ion binding]
GO:0008289 [lipid binding]
GO:0008344 [adult locomotory behavior]
GO:0009410 [response to xenobiotic stimulus]
GO:0010040 [response to iron(II) ion]
GO:0010517 [regulation of phospholipase activity]
GO:0010642 [negative regulation of platelet-derived growth factor receptor signaling pathway]
GO:0014048 [regulation of glutamate secretion]
GO:0014059 [regulation of dopamine secretion]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0016082 [synaptic vesicle priming]
GO:0016234 [inclusion body]
GO:0016491 [oxidoreductase activity]
GO:0019894 [kinesin binding]
GO:0022898 [regulation of transmembrane transporter activity]
GO:0030424 [axon]
GO:0030426 [growth cone]
GO:0030544 [Hsp70 protein binding]
GO:0030672 [synaptic vesicle membrane]
GO:0031092 [platelet alpha granule membrane]
GO:0031115 [negative regulation of microtubule polymerization]
GO:0031623 [receptor internalization]
GO:0031648 [protein destabilization]
GO:0032026 [response to magnesium ion]
GO:0032410 [negative regulation of transporter activity]
GO:0032496 [response to lipopolysaccharide]
GO:0032769 [negative regulation of monooxygenase activity]
GO:0032991 [protein-containing complex]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034341 [response to type II interferon]
GO:0034599 [cellular response to oxidative stress]
GO:0035067 [negative regulation of histone acetylation]
GO:0035493 [SNARE complex assembly]
GO:0035543 [positive regulation of SNARE complex assembly]
GO:0040012 [regulation of locomotion]
GO:0042393 [histone binding]
GO:0042416 [dopamine biosynthetic process]
GO:0042417 [dopamine metabolic process]
GO:0042775 [mitochondrial ATP synthesis coupled electron transport]
GO:0042802 [identical protein binding]
GO:0042995 [cell projection]
GO:0043014 [alpha-tubulin binding]
GO:0043025 [neuronal cell body]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0043030 [regulation of macrophage activation]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043679 [axon terminus]
GO:0045202 [synapse]
GO:0045807 [positive regulation of endocytosis]
GO:0045920 [negative regulation of exocytosis]
GO:0045921 [positive regulation of exocytosis]
GO:0046872 [metal ion binding]
GO:0046928 [regulation of neurotransmitter secretion]
GO:0048156 [tau protein binding]
GO:0048168 [regulation of neuronal synaptic plasticity]
GO:0048169 [regulation of long-term neuronal synaptic plasticity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048488 [synaptic vesicle endocytosis]
GO:0048489 [synaptic vesicle transport]
GO:0050729 [positive regulation of inflammatory response]
GO:0050806 [positive regulation of synaptic transmission]
GO:0050808 [synapse organization]
GO:0050812 [regulation of acyl-CoA biosynthetic process]
GO:0051179 [localization]
GO:0051219 [phosphoprotein binding]
GO:0051259 [protein complex oligomerization]
GO:0051262 [protein tetramerization]
GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol]
GO:0051402 [neuron apoptotic process]
GO:0051583 [dopamine uptake involved in synaptic transmission]
GO:0051585 [negative regulation of dopamine uptake involved in synaptic transmission]
GO:0051612 [negative regulation of serotonin uptake]
GO:0051621 [regulation of norepinephrine uptake]
GO:0051622 [negative regulation of norepinephrine uptake]
GO:0060079 [excitatory postsynaptic potential]
GO:0060090 [molecular adaptor activity]
GO:0060291 [long-term synaptic potentiation]
GO:0060732 [positive regulation of inositol phosphate biosynthetic process]
GO:0061024 [membrane organization]
GO:0070495 [negative regulation of thrombin-activated receptor signaling pathway]
GO:0070555 [response to interleukin-1]
GO:0070840 [dynein complex binding]
GO:0071280 [cellular response to copper ion]
GO:0071872 [cellular response to epinephrine stimulus]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0097435 [supramolecular fiber organization]
GO:0098794 [postsynapse]
GO:0099512 [supramolecular fiber]
GO:1901214 [regulation of neuron death]
GO:1901215 [negative regulation of neuron death]
GO:1901216 [positive regulation of neuron death]
GO:1902957 [negative regulation of mitochondrial electron transport, NADH to ubiquinone]
GO:1903136 [cuprous ion binding]
GO:1903284 [positive regulation of glutathione peroxidase activity]
GO:1903285 [positive regulation of hydrogen peroxide catabolic process]
GO:1903421 [regulation of synaptic vesicle recycling]
GO:1903426 [regulation of reactive oxygen species biosynthetic process]
GO:1904715 [negative regulation of chaperone-mediated autophagy]
GO:1905606 [regulation of presynapse assembly]
GO:1990000 [amyloid fibril formation]
GO:2000377 [regulation of reactive oxygen species metabolic process]
Show all
 140 aa
14.5 kDa 		No 0
SNCA-206
ENSP00000396241
ENST00000420646
P37840
[Direct mapping] Alpha-synuclein
Show all
H6UYS5
[Target identity:100%; Query identity:100%] Alpha-synuclein
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Disease related genes
Potential drug targets
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000149 [SNARE binding]
GO:0000287 [magnesium ion binding]
GO:0000976 [transcription cis-regulatory region binding]
GO:0001774 [microglial cell activation]
GO:0001921 [positive regulation of receptor recycling]
GO:0003779 [actin binding]
GO:0004860 [protein kinase inhibitor activity]
GO:0005507 [copper ion binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005764 [lysosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007268 [chemical synaptic transmission]
GO:0008198 [ferrous iron binding]
GO:0008270 [zinc ion binding]
GO:0008289 [lipid binding]
GO:0010040 [response to iron(II) ion]
GO:0010517 [regulation of phospholipase activity]
GO:0010642 [negative regulation of platelet-derived growth factor receptor signaling pathway]
GO:0014059 [regulation of dopamine secretion]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0016082 [synaptic vesicle priming]
GO:0016234 [inclusion body]
GO:0016491 [oxidoreductase activity]
GO:0019894 [kinesin binding]
GO:0022898 [regulation of transmembrane transporter activity]
GO:0030424 [axon]
GO:0030426 [growth cone]
GO:0030544 [Hsp70 protein binding]
GO:0031092 [platelet alpha granule membrane]
GO:0031115 [negative regulation of microtubule polymerization]
GO:0031623 [receptor internalization]
GO:0031648 [protein destabilization]
GO:0032026 [response to magnesium ion]
GO:0032410 [negative regulation of transporter activity]
GO:0032496 [response to lipopolysaccharide]
GO:0032769 [negative regulation of monooxygenase activity]
GO:0032991 [protein-containing complex]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034341 [response to type II interferon]
GO:0034599 [cellular response to oxidative stress]
GO:0035067 [negative regulation of histone acetylation]
GO:0035493 [SNARE complex assembly]
GO:0035543 [positive regulation of SNARE complex assembly]
GO:0042393 [histone binding]
GO:0042416 [dopamine biosynthetic process]
GO:0042802 [identical protein binding]
GO:0042995 [cell projection]
GO:0043014 [alpha-tubulin binding]
GO:0043025 [neuronal cell body]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043679 [axon terminus]
GO:0045202 [synapse]
GO:0045807 [positive regulation of endocytosis]
GO:0045920 [negative regulation of exocytosis]
GO:0045921 [positive regulation of exocytosis]
GO:0046872 [metal ion binding]
GO:0048156 [tau protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048488 [synaptic vesicle endocytosis]
GO:0050729 [positive regulation of inflammatory response]
GO:0050808 [synapse organization]
GO:0051179 [localization]
GO:0051219 [phosphoprotein binding]
GO:0051262 [protein tetramerization]
GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol]
GO:0051583 [dopamine uptake involved in synaptic transmission]
GO:0051585 [negative regulation of dopamine uptake involved in synaptic transmission]
GO:0051612 [negative regulation of serotonin uptake]
GO:0051621 [regulation of norepinephrine uptake]
GO:0051622 [negative regulation of norepinephrine uptake]
GO:0060090 [molecular adaptor activity]
GO:0060732 [positive regulation of inositol phosphate biosynthetic process]
GO:0070495 [negative regulation of thrombin-activated receptor signaling pathway]
GO:0070555 [response to interleukin-1]
GO:0070840 [dynein complex binding]
GO:0071280 [cellular response to copper ion]
GO:0071872 [cellular response to epinephrine stimulus]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0097435 [supramolecular fiber organization]
GO:0098794 [postsynapse]
GO:0099512 [supramolecular fiber]
GO:1901214 [regulation of neuron death]
GO:1901215 [negative regulation of neuron death]
GO:1901216 [positive regulation of neuron death]
GO:1902957 [negative regulation of mitochondrial electron transport, NADH to ubiquinone]
GO:1903136 [cuprous ion binding]
GO:1903284 [positive regulation of glutathione peroxidase activity]
GO:1903285 [positive regulation of hydrogen peroxide catabolic process]
GO:1903421 [regulation of synaptic vesicle recycling]
GO:1903426 [regulation of reactive oxygen species biosynthetic process]
GO:1904715 [negative regulation of chaperone-mediated autophagy]
GO:1905606 [regulation of presynapse assembly]
GO:1990000 [amyloid fibril formation]
Show all
 112 aa
11.4 kDa 		No 0
SNCA-207
ENSP00000426034
ENST00000502987
E7EPV7
[Direct mapping] Alpha-synuclein
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0014059 [regulation of dopamine secretion]
GO:0016020 [membrane]
GO:0030424 [axon]
GO:0045202 [synapse]
Show all
 115 aa
11.8 kDa 		No 0
SNCA-208
ENSP00000421485
ENST00000505199
P37840
[Direct mapping] Alpha-synuclein
Show all
H6UYS0
[Target identity:100%; Query identity:100%] Alpha-synuclein
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Disease related genes
Potential drug targets
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000149 [SNARE binding]
GO:0000287 [magnesium ion binding]
GO:0000976 [transcription cis-regulatory region binding]
GO:0001774 [microglial cell activation]
GO:0001921 [positive regulation of receptor recycling]
GO:0003779 [actin binding]
GO:0004860 [protein kinase inhibitor activity]
GO:0005507 [copper ion binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005764 [lysosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007268 [chemical synaptic transmission]
GO:0008198 [ferrous iron binding]
GO:0008270 [zinc ion binding]
GO:0008289 [lipid binding]
GO:0010040 [response to iron(II) ion]
GO:0010517 [regulation of phospholipase activity]
GO:0010642 [negative regulation of platelet-derived growth factor receptor signaling pathway]
GO:0014059 [regulation of dopamine secretion]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0016082 [synaptic vesicle priming]
GO:0016234 [inclusion body]
GO:0016491 [oxidoreductase activity]
GO:0019894 [kinesin binding]
GO:0022898 [regulation of transmembrane transporter activity]
GO:0030424 [axon]
GO:0030426 [growth cone]
GO:0030544 [Hsp70 protein binding]
GO:0031092 [platelet alpha granule membrane]
GO:0031115 [negative regulation of microtubule polymerization]
GO:0031623 [receptor internalization]
GO:0031648 [protein destabilization]
GO:0032026 [response to magnesium ion]
GO:0032410 [negative regulation of transporter activity]
GO:0032496 [response to lipopolysaccharide]
GO:0032769 [negative regulation of monooxygenase activity]
GO:0032991 [protein-containing complex]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034341 [response to type II interferon]
GO:0034599 [cellular response to oxidative stress]
GO:0035067 [negative regulation of histone acetylation]
GO:0035493 [SNARE complex assembly]
GO:0035543 [positive regulation of SNARE complex assembly]
GO:0042393 [histone binding]
GO:0042416 [dopamine biosynthetic process]
GO:0042802 [identical protein binding]
GO:0042995 [cell projection]
GO:0043014 [alpha-tubulin binding]
GO:0043025 [neuronal cell body]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043679 [axon terminus]
GO:0045202 [synapse]
GO:0045807 [positive regulation of endocytosis]
GO:0045920 [negative regulation of exocytosis]
GO:0045921 [positive regulation of exocytosis]
GO:0046872 [metal ion binding]
GO:0048156 [tau protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048488 [synaptic vesicle endocytosis]
GO:0050729 [positive regulation of inflammatory response]
GO:0050808 [synapse organization]
GO:0051179 [localization]
GO:0051219 [phosphoprotein binding]
GO:0051262 [protein tetramerization]
GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol]
GO:0051583 [dopamine uptake involved in synaptic transmission]
GO:0051585 [negative regulation of dopamine uptake involved in synaptic transmission]
GO:0051612 [negative regulation of serotonin uptake]
GO:0051621 [regulation of norepinephrine uptake]
GO:0051622 [negative regulation of norepinephrine uptake]
GO:0060090 [molecular adaptor activity]
GO:0060732 [positive regulation of inositol phosphate biosynthetic process]
GO:0070495 [negative regulation of thrombin-activated receptor signaling pathway]
GO:0070555 [response to interleukin-1]
GO:0070840 [dynein complex binding]
GO:0071280 [cellular response to copper ion]
GO:0071872 [cellular response to epinephrine stimulus]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0097435 [supramolecular fiber organization]
GO:0098794 [postsynapse]
GO:0099512 [supramolecular fiber]
GO:1901214 [regulation of neuron death]
GO:1901215 [negative regulation of neuron death]
GO:1901216 [positive regulation of neuron death]
GO:1902957 [negative regulation of mitochondrial electron transport, NADH to ubiquinone]
GO:1903136 [cuprous ion binding]
GO:1903284 [positive regulation of glutathione peroxidase activity]
GO:1903285 [positive regulation of hydrogen peroxide catabolic process]
GO:1903421 [regulation of synaptic vesicle recycling]
GO:1903426 [regulation of reactive oxygen species biosynthetic process]
GO:1904715 [negative regulation of chaperone-mediated autophagy]
GO:1905606 [regulation of presynapse assembly]
GO:1990000 [amyloid fibril formation]
Show all
 126 aa
13.1 kDa 		No 0
SNCA-209
ENSP00000422238
ENST00000506244
P37840
[Direct mapping] Alpha-synuclein
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Disease related genes
Potential drug targets
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000149 [SNARE binding]
GO:0000287 [magnesium ion binding]
GO:0000976 [transcription cis-regulatory region binding]
GO:0001774 [microglial cell activation]
GO:0001921 [positive regulation of receptor recycling]
GO:0003779 [actin binding]
GO:0004860 [protein kinase inhibitor activity]
GO:0005507 [copper ion binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005764 [lysosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007268 [chemical synaptic transmission]
GO:0008198 [ferrous iron binding]
GO:0008270 [zinc ion binding]
GO:0008289 [lipid binding]
GO:0010040 [response to iron(II) ion]
GO:0010517 [regulation of phospholipase activity]
GO:0010642 [negative regulation of platelet-derived growth factor receptor signaling pathway]
GO:0014059 [regulation of dopamine secretion]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0016082 [synaptic vesicle priming]
GO:0016234 [inclusion body]
GO:0016491 [oxidoreductase activity]
GO:0019894 [kinesin binding]
GO:0022898 [regulation of transmembrane transporter activity]
GO:0030424 [axon]
GO:0030426 [growth cone]
GO:0030544 [Hsp70 protein binding]
GO:0031092 [platelet alpha granule membrane]
GO:0031115 [negative regulation of microtubule polymerization]
GO:0031623 [receptor internalization]
GO:0031648 [protein destabilization]
GO:0032026 [response to magnesium ion]
GO:0032410 [negative regulation of transporter activity]
GO:0032496 [response to lipopolysaccharide]
GO:0032769 [negative regulation of monooxygenase activity]
GO:0032991 [protein-containing complex]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034341 [response to type II interferon]
GO:0034599 [cellular response to oxidative stress]
GO:0035067 [negative regulation of histone acetylation]
GO:0035493 [SNARE complex assembly]
GO:0035543 [positive regulation of SNARE complex assembly]
GO:0042393 [histone binding]
GO:0042416 [dopamine biosynthetic process]
GO:0042802 [identical protein binding]
GO:0042995 [cell projection]
GO:0043014 [alpha-tubulin binding]
GO:0043025 [neuronal cell body]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043679 [axon terminus]
GO:0045202 [synapse]
GO:0045807 [positive regulation of endocytosis]
GO:0045920 [negative regulation of exocytosis]
GO:0045921 [positive regulation of exocytosis]
GO:0046872 [metal ion binding]
GO:0048156 [tau protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048488 [synaptic vesicle endocytosis]
GO:0050729 [positive regulation of inflammatory response]
GO:0050808 [synapse organization]
GO:0051179 [localization]
GO:0051219 [phosphoprotein binding]
GO:0051262 [protein tetramerization]
GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol]
GO:0051583 [dopamine uptake involved in synaptic transmission]
GO:0051585 [negative regulation of dopamine uptake involved in synaptic transmission]
GO:0051612 [negative regulation of serotonin uptake]
GO:0051621 [regulation of norepinephrine uptake]
GO:0051622 [negative regulation of norepinephrine uptake]
GO:0060090 [molecular adaptor activity]
GO:0060732 [positive regulation of inositol phosphate biosynthetic process]
GO:0070495 [negative regulation of thrombin-activated receptor signaling pathway]
GO:0070555 [response to interleukin-1]
GO:0070840 [dynein complex binding]
GO:0071280 [cellular response to copper ion]
GO:0071872 [cellular response to epinephrine stimulus]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0097435 [supramolecular fiber organization]
GO:0098794 [postsynapse]
GO:0099512 [supramolecular fiber]
GO:1901214 [regulation of neuron death]
GO:1901215 [negative regulation of neuron death]
GO:1901216 [positive regulation of neuron death]
GO:1902957 [negative regulation of mitochondrial electron transport, NADH to ubiquinone]
GO:1903136 [cuprous ion binding]
GO:1903284 [positive regulation of glutathione peroxidase activity]
GO:1903285 [positive regulation of hydrogen peroxide catabolic process]
GO:1903421 [regulation of synaptic vesicle recycling]
GO:1903426 [regulation of reactive oxygen species biosynthetic process]
GO:1904715 [negative regulation of chaperone-mediated autophagy]
GO:1905606 [regulation of presynapse assembly]
GO:1990000 [amyloid fibril formation]
Show all
 140 aa
14.5 kDa 		No 0
SNCA-210
ENSP00000423445
ENST00000506691
D6RA31
[Direct mapping] Alpha-synuclein
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0014059 [regulation of dopamine secretion]
GO:0016020 [membrane]
GO:0030424 [axon]
GO:0045202 [synapse]
Show all
 66 aa
6.8 kDa 		No 0
SNCA-211
ENSP00000426955
ENST00000508895
P37840
[Direct mapping] Alpha-synuclein
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Disease related genes
Potential drug targets
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000149 [SNARE binding]
GO:0000287 [magnesium ion binding]
GO:0000976 [transcription cis-regulatory region binding]
GO:0001774 [microglial cell activation]
GO:0001921 [positive regulation of receptor recycling]
GO:0003779 [actin binding]
GO:0004860 [protein kinase inhibitor activity]
GO:0005507 [copper ion binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005764 [lysosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007268 [chemical synaptic transmission]
GO:0008198 [ferrous iron binding]
GO:0008270 [zinc ion binding]
GO:0008289 [lipid binding]
GO:0010040 [response to iron(II) ion]
GO:0010517 [regulation of phospholipase activity]
GO:0010642 [negative regulation of platelet-derived growth factor receptor signaling pathway]
GO:0014059 [regulation of dopamine secretion]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0016082 [synaptic vesicle priming]
GO:0016234 [inclusion body]
GO:0016491 [oxidoreductase activity]
GO:0019894 [kinesin binding]
GO:0022898 [regulation of transmembrane transporter activity]
GO:0030424 [axon]
GO:0030426 [growth cone]
GO:0030544 [Hsp70 protein binding]
GO:0031092 [platelet alpha granule membrane]
GO:0031115 [negative regulation of microtubule polymerization]
GO:0031623 [receptor internalization]
GO:0031648 [protein destabilization]
GO:0032026 [response to magnesium ion]
GO:0032410 [negative regulation of transporter activity]
GO:0032496 [response to lipopolysaccharide]
GO:0032769 [negative regulation of monooxygenase activity]
GO:0032991 [protein-containing complex]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034341 [response to type II interferon]
GO:0034599 [cellular response to oxidative stress]
GO:0035067 [negative regulation of histone acetylation]
GO:0035493 [SNARE complex assembly]
GO:0035543 [positive regulation of SNARE complex assembly]
GO:0042393 [histone binding]
GO:0042416 [dopamine biosynthetic process]
GO:0042802 [identical protein binding]
GO:0042995 [cell projection]
GO:0043014 [alpha-tubulin binding]
GO:0043025 [neuronal cell body]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043679 [axon terminus]
GO:0045202 [synapse]
GO:0045807 [positive regulation of endocytosis]
GO:0045920 [negative regulation of exocytosis]
GO:0045921 [positive regulation of exocytosis]
GO:0046872 [metal ion binding]
GO:0048156 [tau protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048488 [synaptic vesicle endocytosis]
GO:0050729 [positive regulation of inflammatory response]
GO:0050808 [synapse organization]
GO:0051179 [localization]
GO:0051219 [phosphoprotein binding]
GO:0051262 [protein tetramerization]
GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol]
GO:0051583 [dopamine uptake involved in synaptic transmission]
GO:0051585 [negative regulation of dopamine uptake involved in synaptic transmission]
GO:0051612 [negative regulation of serotonin uptake]
GO:0051621 [regulation of norepinephrine uptake]
GO:0051622 [negative regulation of norepinephrine uptake]
GO:0060090 [molecular adaptor activity]
GO:0060732 [positive regulation of inositol phosphate biosynthetic process]
GO:0070495 [negative regulation of thrombin-activated receptor signaling pathway]
GO:0070555 [response to interleukin-1]
GO:0070840 [dynein complex binding]
GO:0071280 [cellular response to copper ion]
GO:0071872 [cellular response to epinephrine stimulus]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0097435 [supramolecular fiber organization]
GO:0098794 [postsynapse]
GO:0099512 [supramolecular fiber]
GO:1901214 [regulation of neuron death]
GO:1901215 [negative regulation of neuron death]
GO:1901216 [positive regulation of neuron death]
GO:1902957 [negative regulation of mitochondrial electron transport, NADH to ubiquinone]
GO:1903136 [cuprous ion binding]
GO:1903284 [positive regulation of glutathione peroxidase activity]
GO:1903285 [positive regulation of hydrogen peroxide catabolic process]
GO:1903421 [regulation of synaptic vesicle recycling]
GO:1903426 [regulation of reactive oxygen species biosynthetic process]
GO:1904715 [negative regulation of chaperone-mediated autophagy]
GO:1905606 [regulation of presynapse assembly]
GO:1990000 [amyloid fibril formation]
Show all
 140 aa
14.5 kDa 		No 0
SNCA-212
ENSP00000479604
ENST00000611107
H6UYS7
[Direct mapping] Alpha-synuclein
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0014059 [regulation of dopamine secretion]
GO:0016020 [membrane]
GO:0030424 [axon]
GO:0045202 [synapse]
Show all
 98 aa
10 kDa 		No 0
SNCA-213
ENSP00000484044
ENST00000618500
P37840
[Direct mapping] Alpha-synuclein
Show all
H6UYS0
[Target identity:100%; Query identity:100%] Alpha-synuclein
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Disease related genes
Potential drug targets
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000149 [SNARE binding]
GO:0000287 [magnesium ion binding]
GO:0000976 [transcription cis-regulatory region binding]
GO:0001774 [microglial cell activation]
GO:0001921 [positive regulation of receptor recycling]
GO:0003779 [actin binding]
GO:0004860 [protein kinase inhibitor activity]
GO:0005507 [copper ion binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005764 [lysosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007268 [chemical synaptic transmission]
GO:0008198 [ferrous iron binding]
GO:0008270 [zinc ion binding]
GO:0008289 [lipid binding]
GO:0010040 [response to iron(II) ion]
GO:0010517 [regulation of phospholipase activity]
GO:0010642 [negative regulation of platelet-derived growth factor receptor signaling pathway]
GO:0014059 [regulation of dopamine secretion]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0016082 [synaptic vesicle priming]
GO:0016234 [inclusion body]
GO:0016491 [oxidoreductase activity]
GO:0019894 [kinesin binding]
GO:0022898 [regulation of transmembrane transporter activity]
GO:0030424 [axon]
GO:0030426 [growth cone]
GO:0030544 [Hsp70 protein binding]
GO:0031092 [platelet alpha granule membrane]
GO:0031115 [negative regulation of microtubule polymerization]
GO:0031623 [receptor internalization]
GO:0031648 [protein destabilization]
GO:0032026 [response to magnesium ion]
GO:0032410 [negative regulation of transporter activity]
GO:0032496 [response to lipopolysaccharide]
GO:0032769 [negative regulation of monooxygenase activity]
GO:0032991 [protein-containing complex]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034341 [response to type II interferon]
GO:0034599 [cellular response to oxidative stress]
GO:0035067 [negative regulation of histone acetylation]
GO:0035493 [SNARE complex assembly]
GO:0035543 [positive regulation of SNARE complex assembly]
GO:0042393 [histone binding]
GO:0042416 [dopamine biosynthetic process]
GO:0042802 [identical protein binding]
GO:0042995 [cell projection]
GO:0043014 [alpha-tubulin binding]
GO:0043025 [neuronal cell body]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043679 [axon terminus]
GO:0045202 [synapse]
GO:0045807 [positive regulation of endocytosis]
GO:0045920 [negative regulation of exocytosis]
GO:0045921 [positive regulation of exocytosis]
GO:0046872 [metal ion binding]
GO:0048156 [tau protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048488 [synaptic vesicle endocytosis]
GO:0050729 [positive regulation of inflammatory response]
GO:0050808 [synapse organization]
GO:0051179 [localization]
GO:0051219 [phosphoprotein binding]
GO:0051262 [protein tetramerization]
GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol]
GO:0051583 [dopamine uptake involved in synaptic transmission]
GO:0051585 [negative regulation of dopamine uptake involved in synaptic transmission]
GO:0051612 [negative regulation of serotonin uptake]
GO:0051621 [regulation of norepinephrine uptake]
GO:0051622 [negative regulation of norepinephrine uptake]
GO:0060090 [molecular adaptor activity]
GO:0060732 [positive regulation of inositol phosphate biosynthetic process]
GO:0070495 [negative regulation of thrombin-activated receptor signaling pathway]
GO:0070555 [response to interleukin-1]
GO:0070840 [dynein complex binding]
GO:0071280 [cellular response to copper ion]
GO:0071872 [cellular response to epinephrine stimulus]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0097435 [supramolecular fiber organization]
GO:0098794 [postsynapse]
GO:0099512 [supramolecular fiber]
GO:1901214 [regulation of neuron death]
GO:1901215 [negative regulation of neuron death]
GO:1901216 [positive regulation of neuron death]
GO:1902957 [negative regulation of mitochondrial electron transport, NADH to ubiquinone]
GO:1903136 [cuprous ion binding]
GO:1903284 [positive regulation of glutathione peroxidase activity]
GO:1903285 [positive regulation of hydrogen peroxide catabolic process]
GO:1903421 [regulation of synaptic vesicle recycling]
GO:1903426 [regulation of reactive oxygen species biosynthetic process]
GO:1904715 [negative regulation of chaperone-mediated autophagy]
GO:1905606 [regulation of presynapse assembly]
GO:1990000 [amyloid fibril formation]
Show all
 126 aa
13.1 kDa 		No 0
SNCA-214
ENSP00000500990
ENST00000673718
P37840
[Direct mapping] Alpha-synuclein
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Disease related genes
Potential drug targets
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000149 [SNARE binding]
GO:0000287 [magnesium ion binding]
GO:0000976 [transcription cis-regulatory region binding]
GO:0001774 [microglial cell activation]
GO:0001921 [positive regulation of receptor recycling]
GO:0003779 [actin binding]
GO:0004860 [protein kinase inhibitor activity]
GO:0005507 [copper ion binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005764 [lysosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007268 [chemical synaptic transmission]
GO:0008198 [ferrous iron binding]
GO:0008270 [zinc ion binding]
GO:0008289 [lipid binding]
GO:0010040 [response to iron(II) ion]
GO:0010517 [regulation of phospholipase activity]
GO:0010642 [negative regulation of platelet-derived growth factor receptor signaling pathway]
GO:0014059 [regulation of dopamine secretion]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0016082 [synaptic vesicle priming]
GO:0016234 [inclusion body]
GO:0016491 [oxidoreductase activity]
GO:0019894 [kinesin binding]
GO:0022898 [regulation of transmembrane transporter activity]
GO:0030424 [axon]
GO:0030426 [growth cone]
GO:0030544 [Hsp70 protein binding]
GO:0031092 [platelet alpha granule membrane]
GO:0031115 [negative regulation of microtubule polymerization]
GO:0031623 [receptor internalization]
GO:0031648 [protein destabilization]
GO:0032026 [response to magnesium ion]
GO:0032410 [negative regulation of transporter activity]
GO:0032496 [response to lipopolysaccharide]
GO:0032769 [negative regulation of monooxygenase activity]
GO:0032991 [protein-containing complex]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034341 [response to type II interferon]
GO:0034599 [cellular response to oxidative stress]
GO:0035067 [negative regulation of histone acetylation]
GO:0035493 [SNARE complex assembly]
GO:0035543 [positive regulation of SNARE complex assembly]
GO:0042393 [histone binding]
GO:0042416 [dopamine biosynthetic process]
GO:0042802 [identical protein binding]
GO:0042995 [cell projection]
GO:0043014 [alpha-tubulin binding]
GO:0043025 [neuronal cell body]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043679 [axon terminus]
GO:0045202 [synapse]
GO:0045807 [positive regulation of endocytosis]
GO:0045920 [negative regulation of exocytosis]
GO:0045921 [positive regulation of exocytosis]
GO:0046872 [metal ion binding]
GO:0048156 [tau protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048488 [synaptic vesicle endocytosis]
GO:0050729 [positive regulation of inflammatory response]
GO:0050808 [synapse organization]
GO:0051179 [localization]
GO:0051219 [phosphoprotein binding]
GO:0051262 [protein tetramerization]
GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol]
GO:0051583 [dopamine uptake involved in synaptic transmission]
GO:0051585 [negative regulation of dopamine uptake involved in synaptic transmission]
GO:0051612 [negative regulation of serotonin uptake]
GO:0051621 [regulation of norepinephrine uptake]
GO:0051622 [negative regulation of norepinephrine uptake]
GO:0060090 [molecular adaptor activity]
GO:0060732 [positive regulation of inositol phosphate biosynthetic process]
GO:0070495 [negative regulation of thrombin-activated receptor signaling pathway]
GO:0070555 [response to interleukin-1]
GO:0070840 [dynein complex binding]
GO:0071280 [cellular response to copper ion]
GO:0071872 [cellular response to epinephrine stimulus]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0097435 [supramolecular fiber organization]
GO:0098794 [postsynapse]
GO:0099512 [supramolecular fiber]
GO:1901214 [regulation of neuron death]
GO:1901215 [negative regulation of neuron death]
GO:1901216 [positive regulation of neuron death]
GO:1902957 [negative regulation of mitochondrial electron transport, NADH to ubiquinone]
GO:1903136 [cuprous ion binding]
GO:1903284 [positive regulation of glutathione peroxidase activity]
GO:1903285 [positive regulation of hydrogen peroxide catabolic process]
GO:1903421 [regulation of synaptic vesicle recycling]
GO:1903426 [regulation of reactive oxygen species biosynthetic process]
GO:1904715 [negative regulation of chaperone-mediated autophagy]
GO:1905606 [regulation of presynapse assembly]
GO:1990000 [amyloid fibril formation]
Show all
 140 aa
14.5 kDa 		No 0
SNCA-216
ENSP00000501102
ENST00000673902
A0A669KB41
[Direct mapping] Alpha-synuclein
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0014059 [regulation of dopamine secretion]
GO:0016020 [membrane]
GO:0030424 [axon]
GO:0045202 [synapse]
Show all
 151 aa
15.5 kDa 		No 0
SNCA-217
ENSP00000501269
ENST00000674129
A0A669KBH5
[Direct mapping] Alpha-synuclein
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0014059 [regulation of dopamine secretion]
GO:0016020 [membrane]
GO:0030424 [axon]
GO:0045202 [synapse]
Show all
 159 aa
16.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
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contact@proteinatlas.org