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S100B is widely and predominantly expressed in astrocytes throughout the brain. Additional staining is also reported in neuronal cell bodies from distinct regions of the hindbrain. Interestingly, available RNA data (ISH and RNA-SEQ) agree on an enrichment of S100B in the areas of cerebellum, pons and medulla.
Accordingly, abundant strong immunostaining of astrocytes is noticed throughout the entire brain. Also, strong neuronal somatic immunostaining is noticed in some distrinct midbrain and hindbrain nuclei, like the red nucelus, motor trigeminal nucelus, facial nucleus, lateral paragigantocellular nucelus and some cerebellar nuclei.
Positive cells and structuresi
Manually selected location of the protein positivity, observed by immunofluorescence staining in mouse brain.
Soma and endfeet in astrocytes. Soma in neurons. Endothelia. Choroid plexus, ventricle wall and circumventricular organs of ependymal cells.
The Human Protein Atlas project is funded
