With the recent release of version 24 of the Human Protein Atlas we provide a detailed map of 654 proteins that localize to a small, but important organelle, called the primary cilium. This tiny protrusion is present on most human cell types and serves as a cellular antenna, providing a compartment that is optimal for carefully sensing, transducing and relaying information from the extracellular environment...Read more

During the Nobel week Google in collaboration with KTH hosted an event on AI and science in the spectacular underground Reactor Hall at KTH...Read more

Among the about 20,000 genes in the human proteome there are still many rather unknown but potentially interesting proteins that deserve some extra attention. Here we will focus on RD3L, a less investigated gene related to the Retinal Degeneration Protein 3 (RD3)...Read more

The mucus acinus-specific expression pattern of BPI fold containing family B member 2 (gene: BPIFB2) in salivary gland is highlighted by multiplex immunohistochemistry (mIHC/IF)...Read more

This week, we explore a fascinating protein that regulates the unfolded protein response (UPR) in eukaryotic cells in an unusual manner - by sensing the accumulation of unfolded proteins in the endoplasmic reticulum (ER) lumen and conveying this information to the nucleus. This is achieved through unconventional splicing of the XBP1 mRNA in the cytoplasm leading to the induction of a transcriptional program in the nucleus. Hence its apt name - Endoplasmic Reticulum to Nucleus Signaling, ERN1...Read more