This month, the expression of beta-cell-associated transcription factor PDX1 within the endocrine pancreas is displayed through multiplex immunohistochemistry (mIHC/IF)...Read more

Amyotrophic lateral sclerosis (ALS) is a rare neurodegenerative disorder associated with high morbidity and early mortality. Rapidly progressive cell death of upper and lower motor neurons in the brain as well as in the spinal cord leads to loss of voluntary muscle control. Within a few years of diagnosis, patients lose the ability to move, speak, eat and breath without mechanical support. There is no cure for ALS, with current treatments merely aiming at slowing disease progression and improving symptoms...Read more

The multiplex tissue image of this month showcases the spatial expression pattern of acinar cell-regulating basic helix-loop-helix family member a15 (gene: BHLHA15) in exocrine glandular structures of the salivary gland...Read more

Mitochondria are well known as the energy factories of human cells, but their roles extend well beyond ATP production, with multiple links to other cellular functions continuously being discovered. As can be seen in the subcellular resource of the HPA, the positioning of mitochondria within cells is variable, both between cell types and from cell-to-cell. This arrangement is not random, but rather regulated and highly dynamic. In fact, their proximity and direct interactions with other organelles can regulate cellular processes in these compartments...Read more

In this edition of multiplex tissue image of the month, the expression pattern of ciliogenesis-activating transcription factor FOXJ1 is contrasted with chromatin-regulating protein HMGN3 in fallopian tube...Read more