The localization of Calaxin (gene: CLXN) in ciliated cells is highlighted in fallopian tube by multiplex immunohistochemistry (mIHC/IF)...Read more

Meiosis-associated Boule homolog, RNA binding protein (gene: BOLL) is localized to mid-stage developing sperm in testis with multiplex immunohistochemistry (mIHC/IF)...Read more

The proximal tubule-specific catabolic enzyme myo-inositol oxygenase (gene: MIOX) is highlighted in kidney through multiplex immunohistochemistry (mIHC/IF)...Read more

Histone-like protein Protamine 1 (gene: PRM1) is visualized in the late stage cell states of developing sperm in testis with multiplex immunohistochemistry (mIHC/IF)...Read more

Previously, it was believed that the presence of an oncogenic mutation within a cell was sufficient to drive tumour development. However, it is now understood that tissues may contain cells harbouring oncogenic mutations, but that these cells maintain a normal phenotype until an initiating factor promotes oncogenic transformation (Acha-Sagredo et al, 2021). Changes in the cellular milieu and tissue architecture, such as inflammation or parenchymal density, are thought to alter the behaviour of these cells, affecting the likelihood of oncogenic transformation (Ling et al, 2020; Singh et al, 2019). Nonetheless, the precise mechanisms that underlie cancer promotion, and their association with factors such as smoking or obesity, are not fully understood...Read more