In a report published in the Journal of Proteome Research last years advances and efforts within the Human Proteome Project (HPP) to define the human proteome and make proteomics an integral part of functional multiomics are presented...Read more

Using multiplex immunohistochemistry (mIHC/IF), the spatial expression pattern of transmembrane protein 213 (gene: TMEM213) is displayed in ductal structures of the salivary gland...Read more

We are very happy to see that the HPA primary cilia research by Hansen et al., published in Cell in November, has been recognized as 'setting a new standard for understanding ciliary function and its role in health and disease'. The recent research highlight published in Nature Signal Transduction and Targeted Therapy praises the HPA work as fundamentally transformative for ciliary biology...Read more

Detection of cancer is a challenging task, especially since many common diffuse symptoms overlap with non-malignant conditions. In an article in Nature Communications it was shown that plasma protein profiling can be used to identify cancer among patients with non-specific symptoms...Read more

The ability to balance the amount of cellular components, remove damaged entities and recycle molecules by controlled degradation is crucial for cellular function and homeostasis. Lysosomes play a central role by acting as a major hub for degrading proteins, polysaccharides and lipids delivered by autophagy and endocytosis. This is mediated by various hydrolases, specifically acting in the acidic environment maintained in the lysosomal lumen. The lysosomal degradation chamber is isolated from the rest of the cell by a lipid bilayer containing numerous membrane proteins, which are coordinating the functions of lysosomes in processes such as cell homeostasis, metabolism, signalling and stress responses. The membrane proteins themselves are protected on the luminal side by glycosylation, which is key to lysosomal integrity...Read more