In a study published in Journal of Proteome Research, >180 proteins have been spatially mapped to specific subcellular compartments in cells with motile cilia using multiplex immunohistochemistry. The high-resolution data is available in the HPA Tissue resource, and aids in further functional mapping of proteins with limited evidence...Read more

In a publication in PLOS One researchers have trained a deep learning model to segment epithelial cells based on their different grades of malignity in breast cancer sections using immunohistochemistry stainings as ground truth...Read more

Metastasis formation is a multistep process that involves cancer cell transmigration through tumor vessels and through the healthy vasculature of the affected organ. This process is limited by an intact vascular barrier formed by endothelial cells, ECM, and pericytes. In a publication in JCI Insight, researchers from HPA and Uppsala University studied the role of the protein CD93 in maintaining vascular integrity in metastatic cancers...Read more

In a publication in Journal of Proteome Research transcriptomics and spatial proteomics were used to investigate and validate the expression of so-called missing proteins in the human ovary...Read more

Platelet factor 4 (gene: PF4) is a chemokine expressed by platelets (thrombocytes) - blood cell fragments that play a key role during blood clotting. Although its normal physiological role is not completely understood, PF4 is implicated in antimicrobial activity and life-threatening thrombosis caused by adenovirus vector covid-19 vaccines...Read more